中国全科医学2016，Vol.19Issue(32)：3966-3972,7.DOI:10.3969/j.issn.1007-9572.2016.32.014
硫酸镁联合川芎嗪治疗妊娠期高血压有效性和安全性的 Meta分析
Effects and Safety of Magnesium Sulfate Combined with Ligustrazine on Treatment of Pregnancy -induced Hypertension：A Meta-analysis
摘要
Abstract
Objective To analyze and evaluate the effects and safety of magnesium sulfate combined with ligustrazine on treatment of pregnancy-induced hypertension compared with monotherapy of magnesium sulfate by meta-analysis, and to provide evidence for clinical medication decisions.Methods A computer -based retrieval of CNKI, CBM, Wanfang Data, VIP, China Dissertation Database, Cochrane Library, PubMed, EMBase, OVID, EBSCO were made, and relevant literatures of research group adopting magnesium sulfate combined with ligustrazine, and of control group only using magnesium sulfate in treating pregnancy -induced hypertension were screened. The searching period was from the time of database building to December 2015.The abstracts of literatures were read and literatures were screened of the full text, and necessary data were extracted and induced, including the first author, publishing time, sample size, intervening measures, courses of treatment, outcome indicators, as well as random method, allocation concealment and blinding methods, and other sources of bias; the quality of the included literatures was assessed according to the standard form of quality assessment of Cochrane Handbook for Systematic Reviews of Interventions (5.1.0 version).The total effective rate, incidence of postpartum hemorrhage, incidence of neonatal asphyxia, incidence of fetal distress, and incidence of adverse reactions between the two groups were analyzed using RevMan 5.3 software.Results A total of 16 literatures were enrolled, including 1 369 patients, of which 683 in control group and 686 in research group.13 literatures were randomly divided into groups, of which only one had mentioned the method of blinding in observing and evaluating outcome indicators; allocation concealment were not reported in all the included literatures, and no lost to follow-up and selective reports results were found, and research data were completely provided.The results of meta analysis were shown as follows: compared with control group, the total effective rate of research group was higher 〔RR=1.19, 95%CI (1.13, 1.25)〕, incidence of postpartum hemorrhage 〔RR=0.38, 95%CI (0.25, 0.58)〕, incidence of neonatal asphyxia 〔RR=0.35, 95%CI (0.21, 0.58)〕, and the incidence of fetal distress in uterus 〔RR=0.42, 95%CI (0.26, 0.66)〕, and incidence of adverse reactions 〔RR =0.30, 95%CI (0.15, 0.57)〕 were lower.Conclusion Magnesium sulfate combined with ligustrazine in the treatment of pregnancy-induced hypertension is superior to using magnesium sulfate alone in terms of the following aspects: improving overall clinical efficiency, and reducing rates of postpartum hemorrhage, neonatal asphyxia, fetal distress in uterus, and adverse reactions.关键词
高血压, 妊娠性/硫酸镁/川芎嗪/治疗结果/药物毒性/Meta分析Key words
Hypertension, pregnancy-induced/Magnesium sulfate/Tetramethylpyrazine/Treatment outcome/Drug toxicity/Meta-analysis分类
医药卫生引用本文复制引用
魏晓红,张宇骄,李爱玲,傅晓冬..硫酸镁联合川芎嗪治疗妊娠期高血压有效性和安全性的 Meta分析[J].中国全科医学,2016,19(32):3966-3972,7.基金项目
2014年四川省科学技术厅与泸州市人民政府、泸州医学院联合科研专项资金计划项目(川科发计［2014］10号） （）
