中国全科医学2016，Vol.19Issue(33)：4073-4078,6.DOI:10.3969/j.issn.1007-9572.2016.33.010
新生血管性青光眼患者血清及房水血管内皮生长因子与促红细胞生成素的表达研究
Expression of Vascular Endothelial Growth Factor and Erythropoietin in Serum and Aqueous Humor of Neovascular Glaucoma Patients
摘要
Abstract
Objective To explore the expression of vascular endothelial growth factor( VEGF)and erythropoietin (EPO)in serum and aqueous humor of neovascular glaucoma(NVG)patients. Methods 20 patients with NVG(A group), 20 patients with primary glaucoma( B group)and 20 patients with cataract( C group)were admitted in the First Affiliated Hospital of Gannan Medical University in 2013. The VEGF and EPO in the serum and aqueous humor of 3 groups were measured using enzyme - linked immunosorbent assay(ELISA)method. The expression levels of serum VEGF and EPO mRNA of 3 groups were measured using RT - PCR method. Results There was no significant difference in serum EPO level among 3 groups (P > 0. 05). The serum VEGF level and aqueous humor levels of VEGF and EPO in B group and C group were lower than those in A group(P < 0. 05). The serum VEGF level and the aqueous humor levels of VEGF and EPO in C group were lower than those in B group(P < 0. 05). There was no linear correlation between serum and aqueous humor levels of VEGF and EPO of NVG patients(r values were - 0. 274 and - 0. 182,respectively,P > 0. 05). The expression levels of serum VEGF mRNA in B group and C group were lower than those in A group(P < 0. 05). The expression levels of serum VEGF mRNA in C group were lower than those in B group(P < 0. 05). There was no significant difference in expression level of serum EPO mRNA among 3 groups(P > 0. 05). Conclusion The levels of VEGF,EPO in aqueous humor of NVG patients are higher,and there is no linear correlation between levels of VEGF and EPO in serum and aqueous humor. It suggestes that VEGF and EPO might be independent factors in the pathogenesis of NVG to a certain extent.关键词
青光眼,新生血管性/血管内皮生长因子 A/红细胞生成素/血清/眼房水Key words
Glaucoma,neovascular/Vascular endothelial growth factor A/Erythropoietin/Serum/Aqueous humor分类
医药卫生引用本文复制引用
谢静,王辉,袁思奇,罗耀玲..新生血管性青光眼患者血清及房水血管内皮生长因子与促红细胞生成素的表达研究[J].中国全科医学,2016,19(33):4073-4078,6.基金项目
江西省科技厅科技支撑基金资助项目 （）
