中国药房2016，Vol.27Issue(32)：4490-4492,4493,4.DOI:10.6039/j.issn.1001-0408.2016.32.08
倾向评分匹配法在门诊糖皮质激素处方合理性评价中的应用
Rationality Evaluation of Outpatient Glucocorticoid Prescriptions by Propensity Score Matching
摘要
Abstract
OBJECTIVE:To explore the application of propensity score matching in the rationality evaluation of outpatients glucocorticoid prescriptions. METHODS:1 271 outpatient prescriptions including glucocorticoid drugs in 2015 were selecteds by equal probability cluster sampling from nerth district of our hospital. According to drug package inserts,Guiding Principles for Clin-ical Application of Glucocorticoid Drugs and clinical guidelines,the rationality of glucocorticoid used in prescriptions were judged irrational ones were included in irrational prescriptions (IP) group. Rational prescriptions (RP) group included the same number which were selected from rational prescriptions by propensity score matching (PSM) and were in line with irrational ones in re-spects of gender,age and medical insuranc (P=1). The differences between 2 groups were compared in respects of disease sys-tem,dosage form,route of administration and drug dosage. RESULTS:There were 1 168 rational prescriptions(91.90%)and 103 irrational ones(8.10%)in 1 271 prescriptions. After PSM,2 groups of ochincluded 103 prescriptions,there was no statistical dif-ference between RP group and IP group in terms of dosage form(P=0.962),route of administration(P=0.246)and DDDs(P=0.307). For disease system,disease diagnose of 56 prescriptions(54.4%)in IP groups went beyond guideline principle,while one prescription(1.0%)in RP group,with statistical significance(P<0.001). Among irrational prescription analysis,99 prescriptions (96.1%) were irrational indication,and 4 prescriptions (3.9%) were irrational route of administration. CONCLUSIONS:PSM is helpful to find out the factors inducing irrational prescription,pharmacists should be careful and focus on rationality judgement when they find that disease system is berond guiding principle.关键词
糖皮质激素/处方分析/倾向评分匹配法/合理用药Key words
Glucocorticoid/Prescription analysis/Propensity score matching分类
医药卫生引用本文复制引用
王彧杰,韩璐,原永芳..倾向评分匹配法在门诊糖皮质激素处方合理性评价中的应用[J].中国药房,2016,27(32):4490-4492,4493,4.基金项目
上海交通大学医学院附属第三人民医院科研基金 （）
