中国药房2016，Vol.27Issue(32)：4522-4524,3.DOI:10.6039/j.issn.1001-0408.2016.32.18
精蛋白生物合成人胰岛素注射液（预混30R）强化治疗初发2型糖尿病的临床研究
Clinical Study of Isophane Protamine Biosynthetic Human Insulin Injection(Premix 30R)in the Intensive Treatment of Primary Type 2 Diabetes
摘要
Abstract
OBJECTIVE:To investigate the effects of intensive treatment of Isophane protamine biosynthetic human insulin injection(premix 30R,called“Novolin 30R”for short)on blood glucose,HbA1c and islet B cell function of patients with prima-ry type 2 diabetes. METHODS:68 patients with primary type 2 diabetes were divided into observation group and control group by random number table method,with 34 cases in each group. Control group received acarbose+glimepiride orally;observation group received Novolin 30R subcutaneously,and the dose and times of injection were adjusted according to blood glucose level. The target fasting blood glucose(FBG)and 2 h postprandial blood glucose(2 hPG)were 3.9-7.2 mmol/L and 7.8-10.0 mmol/L. FBG,2 hPG,HbA1c,the time of blood glucose reaching the standard,BMI and islet B cell function were compared between 2 groups. RESULTS:FBG,2 hPG,HbA1c and BMI of 2 groups had no statistical significance before treatment(P>0.05);com-pared to before treatment,FBG,2 hPG and HbA1c of 2 groups were decreased significantly after treatment,and observation group were significantly lower than those of control group;the time of blood glucose reaching the standard was significantly shorter than control group,with statistical significance(P<0.05). There was no statistical significance in BMI between 2 groups before and after treatment(P>0.05). Before treatment,HOMA-IR,HOMA-B and I30/G30 of 2 groups had no statistical signifi-cance (P>0.05);compared to before treatment,HOMA-IR of 2 groups were decreased significantly,while HOMA-B and I30/G30 were increased significantly after treatment;the indexes of observation group was significantly better than that of control group with statistical significance (P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Intensive treatment of Novolin 30R can effectively reduce blood glucose and HbA1c levels of patients with primary type 2 diabetes,shorten the time of blood glucose reaching standard and improve islet B cell function with good safety.关键词
精蛋白生物合成人胰岛素注射液(预混30R)/初发2型糖尿病/强化治疗/血糖/糖化血红蛋白/胰岛B细胞Key words
Isophane protamine biosynthetic human insulin injection(premix 30R)/Primary type 2 diabetes/Intensive treat-ment/Blood glucose/Glycated hemoglobin/Islet B cell分类
医药卫生引用本文复制引用
王郡,周慧敏,董斌,窦婵婵,陈志花,郭艺璇,吕晓静..精蛋白生物合成人胰岛素注射液（预混30R）强化治疗初发2型糖尿病的临床研究[J].中国药房,2016,27(32):4522-4524,3.基金项目
河北省科学技术研究与发展计划项目 （）
