中国药房2016，Vol.27Issue(32)：4525-4527,3.DOI:10.6039/j.issn.1001-0408.2016.32.19
退白颗粒联合窄谱中波紫外线照射治疗寻常型白癜风的疗效观察
Efficacy Observation of Tuibai Granules Combined with NB-UVB Radiation in the Treatment of Vitiligo Vul-garis
摘要
Abstract
OBJECTIVE:To observe the clinical efficacy of Tuibai granules combined with narrow band UVB(NB-UVB)ra-diation in the treatment of vitiligo vulgaris and their effects on ICAM-1 and CXCL9 of peripheral blood. METHODS:60 patients with vitiligo vulgaris were selected and treated with Tuibai granules dissloved in 200 ml water,orally,combined with NB-UVB lo-cal radiation for 3 months. Another 30 healthy volunteers were chosen as control group. Clinical efficacies of different stage,differ-ent skin lesion areas and different disease courses were observed as well as the serum levels of ICAM-1 and CXCL9 before and af-ter treatment,which were compared with control group. RESULTS:Total effective rates of patients were 88.24% in progressive stage,87.10% in those with skin lesion areas <5% and 87.50% in those with disease course<1 year,which were significantly higher than 61.54% in stable stage,65.52% in those with skin lesion area ≥5% and 64.29% in those with disease course ≥1 year,with statistical significance(P<0.05). Before treatment,the levels of ICAM-1 and CXCL9 in all kinds of patients were all higher than in healthy control group;those of progressive stage were higher than those of stable stage;those of skin lesion area ≥5% was higher than those of skin lesion area<5%;those of disease course<1 year was higher than those of disease course ≥1 year,with statistical significance(P<0.05). After treatment,the levels of ICAM-1 and CXCL9 in all kinds of patients were signifi-cantly lower than before except for those in stable stage,with statistical significance(P<0.05). CONCLUSIONS:Tuibai granules combined with NB-UVB radiation shows good therapeutic efficacy in the treatment of vitiligo vulgaris,and can reduce the expres-sion of ICAM-1 and CXCL9.关键词
寻常型白癜风/退白颗粒/黏附分子/趋化因子/疗效Key words
Vitiligo vulgaris/Tuibai granules/ICAM-1/CXCL9/Clinical efficacy分类
医药卫生引用本文复制引用
盛国荣,蒋丽,谢勇,赵婧..退白颗粒联合窄谱中波紫外线照射治疗寻常型白癜风的疗效观察[J].中国药房,2016,27(32):4525-4527,3.基金项目
江苏省药学会百特生物药学基金（No.2015035）；南通市社会发展科技计划项目（No.HS149131）；南通市青年医学人才科研基金 （）
