摘要
Abstract
OBJECTIVE:To explore the preventive effects of dexmedetomidine on postoperative agitation of pediatric sevoflu-rane general anesthesia. METHODS:41 children underwent amygdalectomy/adenoidectomy of general anesthesia were selected and randomly divided into SD group (21 cases) and SN group (20 cases). Both groups received atropine 0.01 mg/kg,cisatracurium 0.15 mg/kg and 8% sevoflurane to induce anesthesia. After intubation,the lungs were clear and equivalent to auscultation bilateral-ly,and then both groups received mechanical ventilation and intravenous pump of remifentanil 0.15 μg/(kg·min). After the opera-tion began,SD group was given dexmedetomidine 0.5 μg/(kg·h)and SN group given normal saline 0.5 μg/(kg·h)via intravenous pump. At the end of operation,anesthetics was discontinued;the children respired autonomously,tidal volume retune to normal, and deglutition reflex and cough reflex recovered;an then the tube could be drawn. Heart rate (HR) and mean arterial pressure (MAP)of 2 groups were recorded before intravenous pump of dexmedetomidine(T1),at 10(T2),20(T3),30 min(T4)after in-travenous pump,at the moment of extubation (T5). Postoperative extubation time and opening eyes,the occurrence of ADR were observed in 2 groups. The degree of postoperative agitation and pain (CHIPPS score) were scored in 2 groups. RESULTS:Com-pared with before treatment,MAP and HR of SD group were decreased at different time points after treatment, but no change was found in SN group; there were statistical significance in MAP and HR between 2 groups at T2-T5(P<0.05). Postoperative extuba-tion time and opening eyes time of SD group were significantly longer than those of SN group,while agitation score immediately after operation,the incidence of agitation and CHIPPS score were significantly lower than SN group,with statistical significance (P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:For pediatric amygdalectomy/adenoidectomy,dexmedetomi-dine as adjunctive drug of general anesthesia prolongs the time of postoperative extubation and opening eyes,but can effectively re-duce postoperative agitation score,the incidence of agitation and CHIPPS score. It helps the children to feel more comfortable dur-ing anesthesia recovery period.关键词
右美托咪定/七氟烷/术后躁动/小儿/全身麻醉Key words
Dexmedetomidine/Sevoflurane/Postoperative agitation/Pediatric/General anesthesia分类
医药卫生
