摘要
Abstract
OBJECTIVE:To observe clinical efficacy and safety of Salvia tetramethylpyrazine injection combined with trimeta-zidinein the treatment of acute phase of viral myocarditis. METHODS:110 patients with acute phase of viral myocarditis were di-vided into control group and observation group according to random number table,with 55 cases in each group. Both groups re-ceived basic treatment as fructose sodium dipllosphate,high-protein diet. Control group was given Trimetazidine hydrochloride tab-let 20 mg,po,tid;observation group was additionally given Salvia tetramethylpyrazine injection 5 ml added into 5% Glucose in-jection 250 ml,ivgtt,qd. Both groups received treatment for consecutive 30 d. The clinical efficacy and therapeutic efficacy of elec-trocardiogram S-T segment were compared between 2 groups. The levels of serum inflammatory factors(IL-6,hs-CRP),oxidative stress factors(MDA,SOD), cardiac enzymes(CK,LDH)and the occurrence of ADR were compared between 2 groups before and after treatment. RESULTS:The total effective rate and total effective rate of electrocardiogram S-T segment in observation group were 94.5% and 90.9%,which was significantly higher than those of control group (85.4% and. 81.8%),with statistical significance(P<0.05). There was no statistical significance in the levels of IL-6,hs-CRP,MDA,SOD,CK and LDH between 2 groups before treatment(P>0.05). After treatment,the levels of IL-6,hs-CRP,MDA,SOD,CK and LDH were decreased signif-icantly in 2 groups,while MDA was significantly increased;the observation group was significantly better than the control group, with statistical significance(P<0.05). There was no statistical significance in the incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Salvia tetramethylpyrazine injection combined with trimetazidine is effective in the treatment of acute phase of vi-ral myocarditis,can effectively improve electrocardiogram and lab indexes with good safety.关键词
丹参川芎嗪注射液/曲美他嗪/病毒性心肌炎/心电图/临床疗效Key words
Salvia tetramethylpyrazine injection/Trimetazidine/Viral myocarditis/Electrocardiogram/Clinical efficacy分类
医药卫生
