摘要
Abstract
OBJECTIVE:To study the possible influential factors of chronic hepatitis B (CHB) recurrent after adefovir ester withdrawal. METHODS:CHB patients receiving adefovir acetate met drug with drawal standard in our hospital during Jan. 2013-Jan. 2015 were selected as the research object. 120 patients suffering from CHB recurrent after drug withdrawal were included in observation group,and 100 patients without CHB recurrent were included in control group. The age,sex,smoking history, drinking history and family history of hepatitis B,biochemical indicators,hepatitis B serology indexes,virology indexes were com-pared between 2 groups as well as the occurrence of ADR. RESULTS:There was no statistical significance in family history of hep-atitis B and smoking history between 2 groups (P>0.05);the proportion of male in observation group was significantly higher than in control group,patients aged 46 years above of observation group was significantly more than those of control group,pa-tients with drinking history was significantly more than control group,with statistical significance (P<0.05). HBV-DNA load of observation group were significantly lower than those of control group,with statistical significance(P<0.05). There was no statisti-cal significance in lab indicators and HBeAg positive rate between 2 groups (P>0.05). No ADR was found in 2 groups during treatment,such as the elevation of serium inorganic phosphorus,creatine kinase,usea nitrogen and creatinine disorder. CONCLU-SIONS:HBV-DNA load,advanced age,female and drinking history may be influential factors of CHB recurrence after drug with-drawal during initial treatment.关键词
阿德福韦酯/慢性乙型肝炎/停药/复发/影响因素Key words
Adefovir ester/Chronic hepatitis B/Withdrawal/Recurrence/Influential factor分类
医药卫生
