摘要
Abstract
Objective To observe the influence and its possible mechanism of sitagliptin to carotid intima-media thickness of patients with type 2 diabetes. Methods 70 cases of patients with type 2 diabetes cured in our hospital from January 2013 to January 2016 were selected and randomly divided into experiment group and control group with 35 cases in each. Patients in experiment group were treated with sitagliptin phosphate and metformin oral for 24 weeks, and patients in control group were treated with acarbose and metformin oral for 24 weeks. Fasting plasma glucose (FGP), 2h postprandial blood glucose (2hPG), glycated hemoglobin (GHbA1C) and carotid intima-media thickness (IMT) of the patients before and after the treatment were determined. Results There were no significant differences on fasting plasma glucose (FGP), 2h postprandial blood glucose (2Hpg), glycated hemoglobin, insulin dosage, carotid intima-media thickness and other results of the two groups before the treatment (P>0.05). After the treatment, fasting plasma glucose, 2h postprandial blood glucose, glycated hemoglobin, insulin dosage, carotid intima-media thickness and other results of the two groups were all different with those before the treatment and those of control group after the treatment(P<0.05). There were no significant differences on the comparison results of BMI, total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein of the two groups before the treatment (P>0.05).There were some differences on the comparison results of BMI,, total cholesterol, Low-density lipoprotein after the treatment(P < 0.05). Conclusion Sitagliptin can effectively reduce blood sugar, and also can improve or prevent atherosclerosis.关键词
西格列汀/2型糖尿病/颈动脉内膜中层厚度Key words
Sitagliptin/Type 2 diabetes/Carotid intima-media thickness分类
医药卫生
