中国中医药信息杂志2016，Vol.23Issue(12)：69-72,4.DOI:10.3969/j.issn.1005-5304.2016.12.017
新疆阿魏乙酸乙酯分离部位对HCT116细胞迁移和侵袭能力的影响
Effects of Separation Parts of Ethyl Acetate from Ferula Sinkiangensis Resin on Migration ;and Invasion of HCT116 Cells
摘要
Abstract
Objective To investigate the effects of separation parts of ethyl acetate from Ferula sinkiangensis resin on migration and invasion of HCT116 cells. Methods In vitro separation parts of ethyl acetate from Ferula sinkiangensis resin with different concentrations were acted on human colon cancer HCT116 cells for 24 h. CCK-8 method was used to detect cell proliferation, calculate the cell growth inhibition rate and IC50. Method of scratches the legitimacy and Transwell room were used to observe HCT116 cell migration ability. Results With the increase of medicine concentration, OD value in Ferula sinkiangensis resin group and cisplatin group decreased gradually;inhibition ratio and medicine concentration were dependent;IC50 was 43.98μg/mL in Ferula sinkiangensis resin group and 36.77μg/mL in cisplatin group. Compared with control group, affected by separation parts of ethyl acetate from Ferula sinkiangensis resin, migration and invasion abilities of HCT116 cells were weakened significantly (P<0.01). Conclusion Separation parts of ethyl acetate from Ferula sinkiangensis resin can reduce proliferation, migration and invasion abilities of HCT116 cells to some extent.关键词
新疆阿魏/人结肠癌HCT116细胞/迁移/侵袭Key words
Ferula sinkiangensis resin/human colon cancer HCT116 cells/migration/invasion分类
医药卫生引用本文复制引用
罗福祥,卢军,张海英..新疆阿魏乙酸乙酯分离部位对HCT116细胞迁移和侵袭能力的影响[J].中国中医药信息杂志,2016,23(12):69-72,4.基金项目
国家自然科学基金 （）
