中国卒中杂志2016，Vol.11Issue(11)：930-933,4.DOI:10.3969/j.issn.1673-5765.2016.11.006
内源性甲醛及炎症介质在血管性痴呆中的研究
The Research of Endogenous Formaldehyde and Inflammatory Medium in the Pathogenesis of Vascular Dementia
武海燕 1马丽 1张力 1曹萌 1张守字 1苏涛 2赫荣乔2
作者信息
- 1. 1100095 北京北京老年医院精神心理科
- 2. 中国科学院生物物理研究所
- 折叠
摘要
Abstract
Objective To evaluate the correlation of inflammatory medium (interleukin-2, IL-2 and tumor necrosis factor-α, TNF-α) and vascular dementia (VaD), so as to provide the biochemical markers for clinical early diagnosis of VaD. <br> Methods A total of 42 patients in outpatient and wards with VaD were taken as experimental group, and 54 cases in the community without cognitive impairment were taken as control group. The level of IL-2 and TNF-α in serum and the formaldehyde concentration (FA) in urine were detected. The FA/Cr was used as rectiifed concentration to compare the differences in above mentioned indexes between two groups. <br> Results The concentration of urine formaldehyde is observably higher in VaD than in the control group (6.31±0.53vs 4.40±0.31), which had statistical signiifcance (P=0.007). <br> Conclusion The concentration of urine formaldehyde in VaD patients was signiifcantly increased. The increased formaldehyde concentration in the urine is expected to be one of the biomarkers in the diagnosis of VaD.关键词
血管性痴呆/内源性甲醛/白介素-2/肿瘤坏死因子Key words
Vascular dementia/Endogenous formaldehyde/Interleukin-2/Tumor necrosis factor-α引用本文复制引用
武海燕,马丽,张力,曹萌,张守字,苏涛,赫荣乔..内源性甲醛及炎症介质在血管性痴呆中的研究[J].中国卒中杂志,2016,11(11):930-933,4.
