动物营养学报2016，Vol.28Issue(11)：3369-3376,8.DOI:10.3969/j.issn.1006-267x.2016.11.001
猪氨基酸代谢节俭机制新假说
A New Hypothesis for the Mechanism of Metabolic Saving of Amino Acids of Pigs
摘要
Abstract
Urinary nitrogen excretion accounts for 60% to 70% of the total nitrogen excretion of pigs. The pro⁃duction rate of urea, which is the main nitrogen⁃containing substance in the urine, to a large extent determines the urinary nitrogen and total nitrogen excretion. Therefore, declining the production rate of urea in liver of pigs is a fundamental approach for reducing total nitrogen excretion. This review summarized the existing nutrition regulatory measures for reducing nitrogen excretion in pigs, characterized the nitrogen direct precursors ( am⁃monia) and indirect precursors ( glycine and alanine) of urea synthesis in liver, and the mechanism of metabol⁃ic fuel function substitution of amino acid ( AA) . On this basis, a new hypothesis for the regulatory mechanism of metabolic saving of AA was proposed, the essence of which is to promote the efficiency of substances like as pyruvate/glucose being as metabolic fuel, decline metabolic rate of AA especially of glutamate, decrease the net flow of nitrogen precursors for urea synthesis in portal vein, urea synthesis in liver and urinary nitrogen ex⁃cretion.关键词
猪/氮排放/氨基酸/代谢节俭/丙酮酸脱氢酶Key words
nitrogen excretion/amino acids/metabolic saving/pyruvate dehydrogenase分类
农业科技引用本文复制引用
孙志洪,李貌,许庆庆,印遇龙,朱伟云,江青艳,黄飞若..猪氨基酸代谢节俭机制新假说[J].动物营养学报,2016,28(11):3369-3376,8.基金项目
国家重点基础研究发展计划（2013CB127300）；农业部＂948＂项目（2015Z74）；国家科技支撑计划课题（2012BAD14B18）；重庆市自然科学基金 （）
