中国妇幼健康研究2016，Vol.27Issue(10)：1195-1197,3.DOI:10.3969/j.issn.1673-5293.2016.10.010
MTHFR和MTRR的SNP多态性与汉族孕妇复发性流产的相关性分析
Correlation analysis of SNP polymorphisms of MTHFR and MTRR with recurrent miscarriage of Han Chinese pregnant women
王开林1
作者信息
- 1. 昆山市第四人民医院妇产科,江苏昆山215331
- 折叠
摘要
Abstract
Objective To explore the correlation of Single nucleotide polymorphisms (SNP) polymorphism of MTHFR and MTRR with recurrent miscarriage of Han Chinese pregnant women.Methods Between January 2012 and February 2015190 non pregnant women with no clear cause of recurrent abortion visiting Kunshan NO.4 People'' s Hospital were selected in observation group, and 180 healthy non pregnant women taking medical examination at the same period were selected in control group.SNP in C677T and A1298C loci of MTHFR gene and A66G locus of MTRR gene were compared between two groups.Results In the observation group frequency distribution of C677T allele in MTHFR gene was significantly higher than in the control group (32.11% vs 21.94%), and the difference was statistically significant (χ2 =9.647,P=0.002).Frequency distribution of A1298C allele in MTHFR gene was 34.47%in the observation group and 30.83%in the control group, and the difference was not significant (χ2 =1.113,P =0.291).In the observation group frequency distribution of A66G allele in MTRR gene was significantly higher than in the control group with statistical significance ( 32.37% vs 15.28%,χ2 =29.558, P=0.000).Conclusion The polymorphism of C677T locus of MTHFR gene and A66G locus of MTRR gene is closely related to recurrent abortion.关键词
MTHFR/MTRR/SNP/汉族孕妇/复发性流产/相关性Key words
methylenetetrahydrofolate reductase ( MTHFR )/methyltransferase reductase ( MTRR )/single nucleotide polymorphisms ( SNP)/Han Chinese pregnant women/recurrent abortion/correlation分类
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王开林..MTHFR和MTRR的SNP多态性与汉族孕妇复发性流产的相关性分析[J].中国妇幼健康研究,2016,27(10):1195-1197,3.
