中国妇幼健康研究2016，Vol.27Issue(10)：1245-1247,1277,4.DOI:10.3969/j.issn.1673-5293.2016.10.026
经阴道不同小剂量米索前列醇在孕晚期引产中的作用比较
Comparison of different low-dose of vaginal misoprostol for induction labor in late pregnancy
曾艳花 1吴雪琴 1邬春霞 1白建团 1李德凤1
作者信息
- 1. 深圳市龙岗中心医院妇产科,广东深圳518116
- 折叠
摘要
Abstract
Objective To compare the effect of different low-dose of vaginal misoprostol on induction of labor in late pregnancy.Methods Totally 170 late pregnant primiparous women with Bishop'' s score≤6 and singleton live pregnancy requiring labor induction were recruited. They were randomly assigned to three groups receiving 12.5μg (n=58), 25μg (n=56) and 50μg (n=56) intravaginal misoprostol, respectively.Induction effectiveness, adverse reactions in labor and neonatal outcomes were compared among three groups.Results There were no significant differences among three groups in labor induction and rate of vaginal delivery.The mean interval between the first dose and active labor was significantly longer in 12.5μg group (26.25 ±5.2hrs) than in 25μg group (8.11 ±3.3hrs) and 50μg group (7.46 ±3.1hrs) (t value was 132 and 111, respectively, both P <0.01).The duration of in labor to expulsion in 12.5μg group (8.53 ±3.5h) was significantly longer than in 25μg group and 50μg group (6.02 ±2.8h, 6.55 ±2.9h) ( t value was 13.77 and 11, respectively, both P<0.01).The need for oxytocin augmentation was higher in 12.5μg group than in 25μg and 50μg group, but there was no statistical significance between 12.5μg group and 25μg group (χ2 value was 0.676 and 5.996,respectively, P value was 0.441 and 0.014, respectively).The incidence of hyperstimulation and abnormal fetal heart rate patterns was significantly higher in 50μg group than in other two groups (χ2 value was 6.127 and 4.553, respectively, P value was 0.013 and 0.033, respectively) .However, there was no significant difference among these groups in adverse neonatal outcomes.Conclusion The low-dose of 50μg, 25μg and 12.5μg misoprostol has good effect on induced labor in late pregnancy, but the interval in 12.5μg group is longer and the adverse reactions of 50μg group are remarkably more.Therefore, the dose of 25μg misoprostol is an appropriate choice for induction labor via vagina.关键词
晚期妊娠/引产/小剂量/米索前列醇Key words
late pregnancy/labor induction/low dose/misoprostol分类
医药卫生引用本文复制引用
曾艳花,吴雪琴,邬春霞,白建团,李德凤..经阴道不同小剂量米索前列醇在孕晚期引产中的作用比较[J].中国妇幼健康研究,2016,27(10):1245-1247,1277,4.
