哈尔滨医药2016，Vol.36Issue(5)：501-503,3.
黄芪对老年急性髓系白血病患者BCL-2家族凋亡因子的相关影响
The Influence of Astragalus on Apoptosis Related Factors Bcl-2’s Famlily in Eld Patients with Acute Myeloid Leukemia
摘要
Abstract
Objective In order to disscuss the underlying treatment mechanism of astragalus on eld patients with acute myeloid leukemia,this study was purposed to investigate the efficacy of astragalus in the treatment of eldly patients with acute myeloid leukemia and the influence of astragalus on atopsoptosis(apoptosis related factors) Bcl-2’s famlily in the patients.Method There were 42 eld patients with AML divided into the treatment and the control groups randomly.Both of the groups were treated with chemotherapy and the treatment group received astragalus more.The rates of complete remission were analysed ,the apoptosis of leukemia cells was quantitatively examined by FCM,the expressions of Bcl-2、BCL-xl、Bax、Bak mRNA were detected by Realtime-PCR before and after therapy,The effectiveness of the two groups would be observed after treatment.Result The complete remission rate of the treatment group was statistically higher than the control one (P<0.05).The apoptosis rates of leukemia cells in the treat-ment group after the therapy were significantly higher than the control group.The mRNA expressions of Bcl-2、BCL-xl、Bax、Bak were especially different from the expressions before therapy in the treatment group (P<0.05).The expressions of Bcl-2 and Bcl-xl were notably lower than before therapy in the treatment group (P<0.05).The Bax and the Bak mRNA expressions were especially higher than before therapy in the treatment group (P<0.05).The mRNA expressions of Bcl-2、BCL-xl、Bax、Bak had no significant difference from the expressions before therapy in the control group (P<0.05).Conclusion Astragalus could promote the process of apoptosis for the leukemia cell and improve the patient’s treatment effect .The mechanism of these may be related to the increases of the apotosis for leukemia cells by reducing the expressions of Bcl-2 and Bcl-xl and promoting the expressions of Bax、Bak.关键词
急性髓系白血病/黄芪/Bcl-2/凋亡Key words
Acute myeloid leukemia/Astragalus/Bcl-2/Atopsoptosis分类
医药卫生引用本文复制引用
余丹,程辉,易雪,张婷..黄芪对老年急性髓系白血病患者BCL-2家族凋亡因子的相关影响[J].哈尔滨医药,2016,36(5):501-503,3.基金项目
武汉市科技局课题<AML白血病干细胞表观遗传学改变的研究初探> （）
