江苏大学学报（医学版）2016，Vol.26Issue(5)：405-409,5.DOI:10.13312/j.issn.1671-7783.y160049
卵巢上皮性癌YAP1和SOX2的表达及其临床意义
Expression of YAP1 and SOX2 in epithelial ovarian carcinoma and their clinical significance
摘要
Abstract
Objective:To investigate the expression of Yes-associated protein1 (YAP1 )and sex-determining region of Y chromosome related high mobility group box 2(SOX2)and their significance in epithelial ovarian carcinoma.Methods:The expression of YAP1 and SOX2 in 86 cases of ovarian carcinoma,and 20 cases of nor-mal ovarian tissue were examined by immunohistochemical staining.Survival time,tumor related clinicopatholog-ical parameters of patients with ovarian cancer were recorded,and their correlation with YAP1 expression was statistically analyzed.The epithelial ovarian cancer cell lines which stable transfected with SOX2 were estab-lished;the expression of SOX2 and YAP1 in the stable cell lines were determined by Western blotting;the mi-gration ability of cells was determined by wound healing assay.Results:The overexpression ratios of YAP1 and SOX2 in ovarian cancer were higher than that in normal ovarian tissue(P<0.01 ).Patients with high-expression YAP1 had shorter survival time than those with low-expression YAP1 (P<0.01 ).The overexpression of YAP1 showed correlation with chemotherapy resistance,metastasis,FIGO stage,and tissue differentiation,but showed no correlation with age.YAP1 overexpression was positively correlated with SOX2 overexpression (r=0.635, P<0.01 ).Comparison with control group,overexpression-SOX2 cells showed higher expression of YAP1 (t=6.304,P<0.01 ),elevated migration ability(t=1 1 .77,P<0.01 ).Conclusion:YAP1 and SOX2 were highly expressed and correlated in epithelial ovarian cancer,which related to the prognosis of epithelial ovarian cancer.关键词
卵巢上皮性癌/Yes相关蛋白1/Y染色体性别决定区相关的高迁移率族盒蛋白2Key words
epithelialovariancarcinoma/Yes-associatedprotein1/sex-determingregionofYchromosome related high mobility group box 2分类
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倪晓鸽,杨佩芳..卵巢上皮性癌YAP1和SOX2的表达及其临床意义[J].江苏大学学报（医学版）,2016,26(5):405-409,5.基金项目
镇江市社会发展项目 （）
