江苏大学学报（医学版）2016，Vol.26Issue(5)：440-443,448,5.DOI:10.13312/j.issn.1671-7783.y160161
半乳糖凝集素3在慢性心力衰竭中的诊断价值
Diagnostic value of galectin-3 in chronic heart failure
摘要
Abstract
Objective:To analyze the correlation between serum galectin-3 (Gal-3)with heart function, left ventricular ejection fraction (LVEF)and B-type natriuretic peptide (BNP)in chronic heart failure (CHF),and evaluate the value of Gal-3 in diagnosis of CHF.Methods:A total of 200 patients with CHF were divided into three groups according to their heart function:NYHA class Ⅱ,class Ⅲ and class Ⅳ;and 200 normal subjects enrolled as control group.Clinic parameters,including triacylglycerol,total cho-lesterol,blood urea nitrogen (BUN ),serum creatinine (SCr),glycosylated hemoglobin (HbA1 c ),BNP and Gal-3 were determined and echocardiography was tested for each participant.Results:Compared with control group,Gal-3 levels in CHF group were significantly elevated [(34.88 ±1 1 .86)μg/L vs.(1 5.67 ± 6.20)μg/L,P<0.01 ].With the deterioration of NYHA heart function in CHF group,concentration of serum Gal-3 increased gradually(P<0.01 ).The correlation analysis showed that the serum Gal-3 concen-tration was positively related to BNP (r=0.504,P<0.01 ),NYHA heart function (r=0.756,P<0.01 ) and negatively related to LVEF (r =-0.678,P <0.01 ).The receiver-operating characteristic curve (ROC)analysis showed that Gal-3 could be a predictor of CHF with an area under the curve (AUC)0.792 (P<0.01 )and the cutoff point for Gal-3 was 1 8 μg/L.Conclusion:The serum Gal-3 concentration in CHF group was significantly elevated,positively related to NYHA heart function and could be used as diag-nostic criteria of CHF.关键词
半乳糖凝集素3/慢性心力衰竭/B型利钠肽Key words
galectin-3/chronicheartfailure/B-typenatriureticpeptide分类
医药卫生引用本文复制引用
姚永伟,陶艾彬,沈冬丽,张国辉,陈蓉..半乳糖凝集素3在慢性心力衰竭中的诊断价值[J].江苏大学学报（医学版）,2016,26(5):440-443,448,5.基金项目
镇江市社会发展项目 （）
