军事医学2016，Vol.40Issue(10)：847-850,4.DOI:10.7644/j.issn.1674-9960.2016.10.017
艰难梭菌tcdC基因的研究进展
Research progress in Clostridium difficile tcdC gene
摘要
Abstract
TcdA and B toxins secreted by Clostridium difficile( CD) are two important causes of diseases in organisms. The expression of tcdA and tcdB genes is regulated by a few factors located in the pathogenicity locus ( PaLoc) .Studies have indicated that the tcdC gene is likely to act as a negative regulator of toxin gene expression.So far, it has been debatable whether tcdC gene is regarded as a negative regulator.The mechanism of tcdC gene in pathogenesis remains unclear.In this paper, the structure and function of the tcdC gene are summarized, which will help study the mechanism of tcdC gene and obtain optimal drug targets.关键词
艰难梭菌/致病性决定区/tcdC基因/毒力Key words
Clostridium difficile/pathogenicity locus/tcdC gene/virulence分类
医药卫生引用本文复制引用
王建霞,王宏伟,冯晓燕,金大智..艰难梭菌tcdC基因的研究进展[J].军事医学,2016,40(10):847-850,4.基金项目
国家自然科学基金资助项目（81471998）；国家卫生计生委科学研究基金－浙江省医药卫生重大科技计划（ WKJ－ZJ－1507）；浙江省重点研发计划资助项目（2015C03G1360012）；全军后勤科研计划资助项目（CWS13J049，AWS15J006）；河北大学研究生创新资助项目 （）
