军事医学2016，Vol.40Issue(10)：851-855,5.DOI:10.7644/j.issn.1674-9960.2016.10.018
基准剂量法在长期暴露毒性评价中的研究进展
Research progress in benchmark dose in risk assessment of long-team exposure toxicity
摘要
Abstract
The purpose of risk assessment is to evaluate the permissible exposure level under specific risk factors.To extrapolate the human acceptable daily intake (ADI) and/or reference dose (RfD), the traditional method uses the no-observed-adverse-effect level ( NOAEL ) to quantify toxicity after being divided by uncertainty factor.There are many limitations with NOAEL method in safety evaluation,for it relies too much on experimental design.Benchmark dose ( BMD) approach is a more reliable method with many advantages.BMD approach and its analysis software, the advantages of BMD over NOAEL, the application and methodological perfection in risk assessment of long-team exposure toxicity are presented in this review.关键词
基准剂量/未观察到有害作用剂量/风险评估/长期暴露毒性Key words
benchmark dose/no-observed-adverse-effect level/risk assessment/long-term exposure toxicity分类
资源环境引用本文复制引用
彭辉,李巧芳,殷健,张廷芬,郭家彬,王以美,彭双清..基准剂量法在长期暴露毒性评价中的研究进展[J].军事医学,2016,40(10):851-855,5.基金项目
国家自然科学基金重点资助项目 （）
