检验医学与临床2016，Vol.13Issue(21)：3021-3022,3025,3.DOI:10.3969/j.issn.1672-9455.2016.21.013
γ-干扰素释放试验对肺结核与肺外结核诊断的敏感性和特异性观察
Sensitivity and specificity of interferon gamma release assay in diagnosis of tuberculosis and extrapulmonary tuberculosis
陈金兰 1全毅 1赵艳兰 1黄书然2
作者信息
- 1. 广西壮族自治区桂林市第三人民医院内三科 541002
- 2. 广西壮族自治区桂林市第三人民医院检验科 541002
- 折叠
摘要
Abstract
Objective To observe sensitivity and specificity of interferon gamma release assay (IGRAs) in the diagnosis of pul‐monary tuberculosis and extrapulmonary tuberculosis .Methods Totally 217 cases of suspected tuberculosis from July 2014 to July 2015 were chosen in the hospital ,and relevant tests for routine and IGRAs were performed in the subjects .All patients were fol‐lowed up for 3 months ,and divided into two groups on the basis of tuberculosis diagnosis ,including the group of confirmed tubercu‐losis (81 cases) and the group of tuberculosis without evidence group (136 cases) .The results of IGRAs were observed .Results In the IGRAs test ,sensitivity was 93 .83% (76/81) ,which of the IGRAs in diagnosis of tuberculosis and extrapulmonary tuberculosis were 95 .74% and 91 .17% ,respectively .And there was no significant difference in sensitivity(P>0 .05) .Specificity of IGRAs was 84 .56% (115/136) ,which of the IGRAs in diagnosis of tuberculosis and extrapulmonary tuberculosis were 80 .00% and 91 .07% , and the specificity of extrapulmonary tuberculosis was significantly higher than that of tuberculosis(P<0 .05) .The sensitivity and specificity in the five units of skin test were 56 .79% and 62 .50% respectively .And the sensitivity ,specificity ,positive predictive value ,negative predictive value in IGRAs test were significantly higher than in tuberculin skin test (TST)(P<0 .05) .Conclusion IGRAs has higher sensitivity and specificity in the diagnosis of tuberculosis and extrapulmonary tuberculosis ,which has higher clin‐ical value especially on excluding the diagnosis of tuberculosis .关键词
γ干扰素释放试验/肺结核/肺外结核/诊断/价值Key words
gamma interferon release test/tuberculosis/extrapulmonary tuberculosis/diagnosis/value引用本文复制引用
陈金兰,全毅,赵艳兰,黄书然..γ-干扰素释放试验对肺结核与肺外结核诊断的敏感性和特异性观察[J].检验医学与临床,2016,13(21):3021-3022,3025,3.
