检验医学与临床2016，Vol.13Issue(21)：3029-3031,3.DOI:10.3969/j.issn.1672-9455.2016.21.016
冠心病患者血清脂蛋白相关磷脂酶A2水平与冠状动脉斑块稳定性的关系
Association between the change of serum lipoprotein associated phospholipase A2 level and the stability of coronary artery plaque in patients with coronary artery disease
邱谷 1刘培龙 1朱俊泉 2戴世荣 1张曙晴1
作者信息
- 1. 江苏省南通市第二人民医院检验科 226002
- 2. 江苏省南通市第二人民医院心内科 226002
- 折叠
摘要
Abstract
Objective To observe the association between the serum lipoprotein associated phospholipase A2 (Lp‐PLA2) level and the stability of coronary artery plaque in patients with coronary artery disease (CAD) .Methods Totally 126 CAD patients with CAD were selected ,including 31 patients with stable CAD (SCAD) ,68 patients with unstable angina pectoris (UAP) and 27 patients with acute myocardial infarction (AMI) .And 119 healthy people were selected as control group .The concentrations of ser‐um Lp‐PLA2 ,ischemia modified albumin (IMA) ,high sensitive C reactive protein (hs‐CRP ) ,procalcitonin (PCT ) and lipids were determined in all the subjects .The test results were compared and analyzed .Results The level of serum Lp‐PLA2 in patients with CAD and control group were (265 .2 ± 23 .4)ng/mL and (166 .3 ± 15 .3)ng/mL respectively .The level of Lp‐PLA2 in patients with CAD was significantly higher than that of healthy controls(P<0 .01) .Lp‐PLA2 was positively correlated with low density lipopro‐tein cholesterol (LDL)(r=0 .522 ,P< 0 .01) ,apolipoprotein B (apoB) (r=0 .516 ,P<0 .01) and was correlated with IMA(r=0 .227 ,P=0 .039) .While it was not correlated with hs‐CRP(r=0 .077 ,P=0 .245) and PCT(r=0 .012 ,P=0 .871) .The level of se‐rum Lp‐PLA2 in the patients with SCAD group ,UAP group and AMI group were (192 .3 ± 18 .3) ,(266 .9 ± 22 .4) and (284 .1 ± 34 .2)ng/mL .The level of Lp‐PLA2 increased with the degree of coronary artery plaque instability(P<0 .01) .Conclusion Lp‐PLA2 level in patients with coronary artery disease is significantly higher than that of healthy controls .Lp‐PLA2 is correlated with important inlipid metabolism ,especially with metabolism of LDL .As a new kind of inflammation markers ,Lp‐PLA2 is closely asso‐ciated with stability of coronary artery plaque .So it is a good evaluate indicator for evaluation of coronary artery disease .关键词
脂蛋白相关磷脂酶A2/冠心病/冠状动脉斑块Key words
lipoprotein associated phospholipase A2/coronary artery disease/coronary artery plaque引用本文复制引用
邱谷,刘培龙,朱俊泉,戴世荣,张曙晴..冠心病患者血清脂蛋白相关磷脂酶A2水平与冠状动脉斑块稳定性的关系[J].检验医学与临床,2016,13(21):3029-3031,3.
