摘要
Abstract
Objective To investigate the effect of prednison combined with cytoxan (CTX) on the efficacy and renal function pa‐rameters in patients with immunoglobulin A (IgA) nephropathy .Methods A total of 86 cases with IgA nephropathy patients were divided into observation group(n=43) and control group(n= 43) from June 2013 to June 2015 .The control group groups were treated with prednison ,while the observation groups were given the treatment of prednison combined with CTX ,and both groups were continuously treated for 12 weeks .The efficacy and renal function indexes of two groups were compared .Results The total effective rates of observation group and control group were 97 .67% and 79 .07% ,respectively ,and the difference was statistically significance (P<0 .05) .The levels of treatment urea nitrogen (BUN) ,serum creatinine (Scr) ,24 h urine protein of observation groups were (4 .33 ± 1 .24) mmol/L ,(85 .36 ± 5 .85) mol/L and (1 .89 ± 0 .24) g after treatment ,which were all significantly lower than that of the control group [(6 .32 ± 2 .02)mmol/L ,(158 .25 ± 8 .36) mol/L and (4 .22 ± 0 .32)g](P<0 .05) .Meanwhile ,endog‐enous creatinine clearance rate (Ccr) (85 .98 ± 14 .02) was significantly higher than that of the control group (68 .23 ± 12 .02) (P<0 .05) .The levels of renal vascular index ,blood pellets index ,tubular‐interstitial index ,crescent index of observation group after treatment were (2 .12 ± 0 .96) points ,(2 .12 ± 0 .88) points ,(2 .02 ± 0 .85) points and 0 .22 ± 0 .08 respectively ,which were signifi‐cantly lower than that of the control group [(3 .02 ± 0 .85) points ,(3 .85 ± 1 .22) points ,(3 .12 ± 0 .96) points and 0 .48 ± 0 .10] (P<0 .05) .Adverse reaction rate between the two groups were not statistically significant (P>0 .05) .Conclusion Prednison com‐bined with CTX can improve clinical efficacy of patients with IgA nephropathy ,as well as improve renal function ,which has lower rate of adverse reactions .In addition ,it is a safe and effective method ,which is worthy of clinical application .关键词
泼尼松/环磷酰胺/原发性免疫球蛋白A肾病/疗效/肾功能指标Key words
prednison/cytoxan/primary immunoglobulin A nephropathy/efficacy/renal function index
