生物技术通报2016，Vol.32Issue(11)：52-58,7.DOI:10.13560/j.cnki.biotech.bull.1985.2016.11.007
p53参与代谢调控的研究进展
Research Progress on p53-involved Metabolic Regulation
摘要
Abstract
As a tumor suppressor,p53 not only is involved in the stress regulation of genetic toxicity,but also plays an important role in the regulation of metabolic balance. When the cells are in different physiological stresses,the activated p53 will affect various metabolic pathways by participating in the regulations of glucose metabolism,fatty acid metabolism,and ROS level. Consequently,the metabolic stress was generated by firstly inducing the occurrence of cell cycle arrest,repair,senescence or apoptosis and finally regulating the organisms and cells. This review summarized the current advances of p53 pathxxray, and discussed the role that p53 played in cancer and metabolic syndrome, which might benefit the study of p53 involved in metabolic regulation.关键词
p53/代谢应激/能量代谢/代谢调控Key words
p53/metabolic stress/energy metabolism/metabolic regulation引用本文复制引用
陈珂,丁艳平,王建林,邵宝平..p53参与代谢调控的研究进展[J].生物技术通报,2016,32(11):52-58,7.基金项目
国家自然科学基金项目（31000190，31060141），神经科学国家重点实验室开放课题 （）
