天津中医药2016，Vol.33Issue(11)：668-671,4.DOI:10.11656/j.issn.1672-1519.2016.11.09
消异方治疗子宫内膜异位症的疗效观察及安全性分析
Efficacy and safety of Xiaoyi formula in the treatment of endometriosis
摘要
Abstract
Objective] To observe the efficacy and safety of Xiaoyi formula in treating endometriosis. [Methods] The 60 patients diagnosed as endometriosis were randomly divided into two groups,30 cases of treatment group administered capsule of Xiaoyi formula and 30 cases of control group given gestrinone. The pain score was evaluated with Visual analogue scale (VAS). The size of endometrial cysts and resistance indexes (RI) of uterine arteries were evaluated with ultrasonography. The serum CA125 levels was determined by ELISA. The incidence of adverse reactions, which included to acne, dysfunction of liver, colporrhagia, dyslipidemia and weight gain, was also observed. The differences of these indicators were compared before and after treatment. [Results] The VAS scores, size of endometrial cysts as well as CA125 levels in both group decreased significantly,but the differences of the changes were not significant (P>0.05). The differences of the total effects rates were not statistically significant (P>0.05). RI in treatment group decreased significantly (P<0.05). The incidence adverse effects in treatment group were significantly lower than the control group (P<0.05). [Conclusion] Clinically, Xiaoyi formula is as effective as gestrinone capsules, and it is safer than gestrinone capsules.关键词
消异方/子宫内膜异位症/疗效观察/安全性分析Key words
Xiaoyi formula/endometriosis/clinical effect observation/safety analysis分类
医药卫生引用本文复制引用
刘霞,肖新春..消异方治疗子宫内膜异位症的疗效观察及安全性分析[J].天津中医药,2016,33(11):668-671,4.基金项目
陕西省教育厅科学基金项目（08JK268）；陕西省科技厅自然科学研究基础项目（青年项目）（2010JQ4008）。 （）
