天津中医药2016，Vol.33Issue(11)：682-685,4.DOI:10.11656/j.issn.1672-1519.2016.11.12
血栓通注射液对血管性痴呆大鼠的行为学改善作用研究
Study of the behavioral improvement effects of Xueshuantong for injection on vascular dementia rats
摘要
Abstract
Objective] To research the behavioral improvement effects of Xueshuantong for injection (lypolized) in curing vascular dementia (VD) rats. [Methods] SD rats were randomly divided into 4 groups (n=20 per group):Sham group, Model group, Tacrine (Control) group and Xueshuantong group. All groups in addition to sham group received a surgery called bilateral common carotid artery occlusion (BCCAO) to establish VD models. The survival quality of all rats was recorded. Water morris and Y-maze were taken to be behavioral test. [Results] Compared with model group, there was no statistical significance among all groups in death rate and weight’s change of rat. Compared with sham group, learning and memory ability of model group dropped with a reduced number of crossing the platform (P<0.01) in water morris test. Compared with model group, Xueshuantong could increase the number of crossing the platform (P<0.01) in water morris test which is the same as Tacrine group. Compared with model group, spatial memory ability of low dose group (Xueshuantong) obviously improved in Y-maze test. [Conclusion] Xueshuantong for injection (lypolized) could improve learning and memory ability of VD rats.关键词
血管性痴呆/行为学/水迷宫/注射用血栓通Key words
vascular dementia/behavioral test/water morris,/Xueshuantong for injection分类
医药卫生引用本文复制引用
王金鑫,杨红云,郭虹,柴丽娟,张玥,王少峡,胡利民..血栓通注射液对血管性痴呆大鼠的行为学改善作用研究[J].天津中医药,2016,33(11):682-685,4.基金项目
“重大新药创制”科技重大专项课题（2012ZX09101201-004）；天津市应用基础与前沿技术研究计划（14JCY－BJC28900）；广西科学研究与技术开发计划（14125008-2-5）。 （）
