天津中医药2016，Vol.33Issue(11)：686-688,3.DOI:10.11656/j.issn.1672-1519.2016.11.13
芪珀生脉颗粒对心气虚小鼠心功能的影响
Effect of Qipo Shengmai granules on cardiac function in mice models of heart Qi deficiency syndrome
摘要
Abstract
Objective] Applied with echocardiography to observe the heart function change of heart Qi deficiency mice and evaluate the effect of Qipo Shengmai granules. [Methods] The model of heart Qi deficiency in mice was established by the method of controlling food, forced swimming and given large dose of propranolol. Kunming mice were randomly divided into normal control group, model group, positive control group and Qipo Shengmai granules high/medium/low dose group. After 14 days of administration, the changes of cardiac function refers to LVIDs, LVIDd, LVPWd, LVPWs, IVSd, IVSs, LVEDV, LVESV, EF, FS, in mice were determined. [Results] Compared with the model group and positive control group, the cardiac function of model group was significantly decreased. Compared with the positive control group, Qipo Shengmai granules high/medium dose group heart function improved significantly (P<0.05 or P<0.01). [Conclusion] Qipo Shengmai granules improves cardiac function in heart Qi deficiency mice.关键词
芪珀生脉颗粒/心气虚/心功能Key words
Qipo Shengmai granule/heart Qi deficiency/heart function分类
医药卫生引用本文复制引用
陈雯,胡元会,师帅,石晶晶,王彦云..芪珀生脉颗粒对心气虚小鼠心功能的影响[J].天津中医药,2016,33(11):686-688,3.基金项目
北京市科委“十病十药”研发专项G20工程支撑保障（Z151100003815012）。 （）
