现代妇产科进展2016，Vol.25Issue(11)：818-820,824,4.DOI:10.13283/j.cnki.xdfckjz.2016.11.004
CCNB1在卵巢癌中的表达及意义
Expression and significance of CCNB1 in ovarian carcinoma
李莉 1熊国平 1颜琳 1张庆华1
作者信息
- 1. 武汉市中心医院妇产科，武汉 430000
- 折叠
摘要
Abstract
Objective:To explore the expression and prognostic value of cyclin B1 (CCNB1) in ovarian carcinoma(OC). Methods:The mRNA level of CCNB1 in OC tissues and the corresponding normal tissues were obtained from the Oncomine database by Real-time PCR. The prognostic value of CCNB1 was retrieved from an online survival analysis tool“the Kaplan Meier plotter”( KM plotter) database. Results:In Oncomine database,there were 18 studies of different types involved CCNB1 expression in OC and normal tissues, of which 18 studies showed up-regulated of CCNB1 in OC ( P<0 . 05 ) . The same result was got from Real-time PCR in 9 pairs of tissues of OC specimens and in the adjacent non-cancerous tissues. In KM plotter database,OC patients with high expression of CCNB1 showed a worse progression-free-survival (PFS) (P<0. 05) and worse overall survival(OS)(P<0. 05). CCNB1's high expression was associated with worsen OS in early stages ( stage I and stage 1+2 ) , while not for late stages ( stage 3 or later) . Conclusions:CCNB1 was highly expressed in OC,which may used as a bio-marker predicted poor outcome.关键词
卵巢癌/预后/CCNB1/KM plotterKey words
Ovarian carcinoma/Prognosis/CCNB1/KM plotter分类
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李莉,熊国平,颜琳,张庆华..CCNB1在卵巢癌中的表达及意义[J].现代妇产科进展,2016,25(11):818-820,824,4.
