现代妇产科进展2016，Vol.25Issue(11)：830-833,837,5.DOI:10.13283/j.cnki.xdfckjz.2016.11.007
3种不同超促排卵方案在高龄患者体外受精-胚胎移植中的临床效果分析
Clinical efficacy of three controlled ovarian hyperstimulation protocols in advanced age undergoing in vitro fertilization and embryo transfer
杨菁 1冯亭亭 1孙伟 2冯雪花 2冯晓军 2贾婷2
作者信息
- 1. 武汉大学人民医院生殖中心，武汉 430060
- 2. 山东中医药大学第二附属医院生殖医学中心，济南 250001
- 折叠
摘要
Abstract
Objective:To assess the efficacy of different controlled ovarian hyperstimu-lation protocols in advanced age (36~45 years) on pregnancy outcome undergoing in vitro fer-tilization and embryo transfer. Methods:A retrospective analysis was performed in a total of 484 cycles,which were divided into three groups with different stimulation protocols:GnRH-a long protocol group( Group A,148 cycles);GnRH-ant protocol group ( Group B,165cycles);ultra-short GnRH-a protocol ( Group C,171 cycles). The general conditions and the clinical out-comes of the three groups were compared. Results:The level LH on hCG injection day in group A was significantly lower than that in group B and group C. Group A had the longest duration of gonadotrophin administration,obtained the most number of eggs,2PN fertilization,2PN cleav-age,high-quality embryos and frozen embryos (P<0. 05). Group C had the most total dose of Gn,the least number of 2PN fertilization,2PN cleavage (P<0. 05). There were no statistical differences between the three groups in endometrial thickness,number of embryos transferred, cycle cancelled rate,early abortion rate and live birth rate (P>0. 05). Embryo implantation rate and clinical pregnancy rate in group A was the highest, the second in group B, the lowest ingroup C,while there was significant difference between group A and group C. Conclusion:Gn-RH-a long protocol has a better clinical outcome for advanced age with relatively better ovarian reserve function;for advanced age with poor ovarian reserve,GnRH-ant protocol has an accepta-ble clinical outcome and may be a valid alternative and comparative economic strategy,while re-quiring relatively less Gn dosage.关键词
高龄/体外受精-胚胎移植/GnRH-a长方案/拮抗剂方案/GnRH-a超短方案Key words
Advanced age/In vitro fertilization and embryo transfer/GnRH-a long protocol/GnRH-ant protocol/Ultrashort GnRH-a protocol分类
医药卫生引用本文复制引用
杨菁,冯亭亭,孙伟,冯雪花,冯晓军,贾婷..3种不同超促排卵方案在高龄患者体外受精-胚胎移植中的临床效果分析[J].现代妇产科进展,2016,25(11):830-833,837,5.
