现代妇产科进展2016，Vol.25Issue(11)：834-837,4.DOI:10.13283/j.cnki.xdfckjz.2016.11.008
转甲状腺蛋白在重度子痫前期及胎儿生长受限孕妇血清中的表达及意义
Expression and significance of serum transthyretin in severe preeclampsia in combination with fetal growth restriction
马红梅 1张震宇 2刘崇东 2赵秀伶 1麻秀丽 1王小兰3
作者信息
- 1. 首都医科大学附属北京潞河医院妇产科，北京 101100
- 2. 首都医科大学附属北京朝阳医院妇产科，北京 100020
- 3. 中国煤炭总医院妇产科，北京 100028
- 折叠
摘要
Abstract
Objective:To investigate the transthyretin ( TTR ) level in maternal serum in patients with severe preeclampsia ( sPE) with and without fetal growth restriction ( FGR) . Methods:The TTR level in maternal serum was measured using enzyme-linked immunosorbent assay ( ELISA) in 120 pregnant women from Beijing Luhe hospital during Sep. 2012 to Feb. 2015. Four groups were classified as follows:severe preeclampsia (sPE group,n=30),fetal growth restriction (FGR group,n=30),severe preeclampsia in combination with fetal growth restriction (sPE+FGR group,n=30),and healthy pregnant women (control group,n=30). Ma-ternal clinical data included age, gravity, parity and gestational age were analyzed. Results:There was no significant differences with age,gravity,parity and gestation age among the four groups. Serum TTR levels in sPE group,FGR group and sPE+FGR group were lower than that control group (P<0. 01). Furthermore,serum TTR levels in sPE group were significantly lower compared with the FGR group ( P<0 . 01 ) . Conclusions:TTR levels were significantly lower in pregnant women with sPE,FGR and sPE+FGR,and it may be used as a potential biomarker of sPE and FGR. Thus, fetal growth restriction may share the same pathological mechanism with preeclampsia.关键词
转甲状腺蛋白/重度子痫前期/胎儿生长受限Key words
Transthyretin/Severe preeclampsia/Fetal growth restriction分类
医药卫生引用本文复制引用
马红梅,张震宇,刘崇东,赵秀伶,麻秀丽,王小兰..转甲状腺蛋白在重度子痫前期及胎儿生长受限孕妇血清中的表达及意义[J].现代妇产科进展,2016,25(11):834-837,4.
