疑难病杂志2016，Vol.15Issue(11)：1116-1119,4.DOI:10.3969/j.issn.1671-6450.2016.11.005
BiPAP无创通气联合特布他林及氨溴索治疗重度慢性阻塞性肺疾病患者的临床效果观察
Clinical effect of BiPAP noninvasive ventilation combined with terbutaline and ambroxol in severe COPD patients
摘要
Abstract
Objective To observe the clinical effect of severe chronic obstructive pulmonary disease (COPD) pa-tients treated by BiPAP noninvasive ventilation combined with terbutaline and ambroxol.Methods From June 2014 to 2015 October, 100 patients of severe COPD from PLA 474 hospital were enrolled as object of observation.They divided into nonin-vasive ventilation group (45 case) and Combined treatment group (55 case), noninvasive ventilation group treated by BiPAP noninvasive ventilation, Combined treatment group treated by BiPAP noninvasive ventilation combined with terbutaline and am-broxol.Clinical effect by Pulmonary function, blood gas indexes and serum inflammatory cytokines levels before and after treatment, adverse reaction conditions were observed.Results The total effective rate in observation group was significantly higher than the control group (98.2% vs.84.4%,χ2 =6.346, P =0.012); the indexes of lung function before treatment in 2 groups of 6 minute walk test (6MWT), forced vital capacity (FVC), forced expiratory volume in one second (FEV1 ), FEV1 /FVC, maximal mid -expiratory flow (MMEF) and the peak expiratory flow rate (PEF) had no statistical significance of PaO2 , pH and blood gas index and PaCO2 level difference ( P >0.05).After treatment, the 2 groups of patients with lung function index and PaO2 and pH were higher than that before treatment, PaCO2 was lower than before treatment, and the ob-servation group changed more obviously than that in control group ( P <0.05); before treatment, no significant difference be-tween the 2 groups of patients with IL-8, IL-17, hs-CRP, TNF-αindex ( P >0.05).After treatment, the indexes of the 2 groups of patients were lower than that before treatment, and the observation group decreased more obvious than the control group ( P <0.05).No adverse reactions occurred in 2 groups of patients.Conclusion BiPAP noninvasive ventilation com-bined with terbutaline and ambroxol has better therapeutic effect in the treatment of severe COPD patients, can significantly improve the patient's lung function and blood gas levels.关键词
无创通气/慢性阻塞性肺疾病/特布他林/氨溴索/肺功能Key words
Noninvasive ventilation/Chronic obstructive pulmonary disease/Terbutaline/Ambroxol/Pulmonary function引用本文复制引用
加尔肯・拉斯拜,兰秋艳,李军梅..BiPAP无创通气联合特布他林及氨溴索治疗重度慢性阻塞性肺疾病患者的临床效果观察[J].疑难病杂志,2016,15(11):1116-1119,4.基金项目
新疆维吾尔族自治区科技支疆（指令性）项目 （）
