摘要
Abstract
Objective To observe the effects of vildagliptin metformin in patients with type 2 diabetic nephropathy se-rum inflammatory factors and curative effect.Methods In this research, we choose some patients with type 2 diabetic ne-phropathy who came to our hospital from January 2014 to June 2015.They were randomly divided into combined group and control group, each group of 32 people.Every patient received conventional diabetes treatment of "Five Keys", including Ex-ercise therapy, medical education, diet, blood glucose monitoring and medications.The control group takes metformin and the combined group adds vildagliptin on the basis of the former.They continue this treatment for 6 months.Before and after re-ceiving treatment, monitor all patients with serum TNF-α, IL-6 and IL-8 level and fasting plasma glucose and 2 hour postpran-dial blood glucose, also including urinary albumin excretion rate.When the end of treatment, all patients were to determine the efficacy.Results Combined treatment group, the total effective rate was 93.75%, significantly higher than the control group 71.88% (χ2 =5.379, P <0.05).Before treatment, there was no significant difference in serum levels of TNF-α, IL-6 and IL-8 between the 2 groups ( P >0.05).Compared with before treatment,the combination group after treatment were lower ( P <0.05), while the control group was not changed significantly after treatment ( P >0.05).There was no signifi-cant difference in FPG, 2h PPG and UREA between the 2 groups before treatment.After treatment, the 2 groups were signifi-cantly reduced, and the combined group was significantly lower than the control group ( P <0.05).Digestive tract reaction, skin allergy and hypoglycemia were found in the 2 groups, but the difference was not statistically significant ( P >0.05). Conclusion Vildagliptin and metformin in treatment of type 2 diabetic nephropathy can reduce serum TNF-α, IL-6 and IL-8 levels, had better glycemic control effect and good safety, can further promote the use of it.关键词
维格列汀/二甲双胍/2 型糖尿病肾病/TNF-α/IL-6/IL-8Key words
Vildagliptin/Metformin/Type 2 diabetic nephropathy/TNF-α/IL-6/IL-8
