Abstract
Objective To observe the curative effect of blood purification assisted multiple myeloma nephropathy and its effect on serum creatinine, blood uric acid.Methods A total of 74 cases of multiple myeloma nephropathy patients treated in hospital from June 2009 to June 2015 were selected as research subjects, according to the random number table method, they were divided into observation group 37 cases and control group 37 cases, the control group was chemotherapy with VAD regimen, observation group with blood purification treatment, after renal function improvement combined with VAD chemother-apy.Two groups of patients treated 4 weeks for 1 course, continuous treatment for 3 courses evaluation clinical efficacy.The recently clinical efficacy, serum creatinine, serum calcium, serum uric acid level, immune globulin, light chain protein levels and adverse reactions occur and survival of 3 years were compared between two groups.Results The observation group in the total efficiency was 78.4% (29 /37), which was higher than that of the control group 56.8% (21 /37), (χ2 =3.947, P =0.047); in observation group, serum creatinine, uric acid, calcium, light chain protein level was significantly lower than the control group ( t =19.081, t =1.979, t =5.877, t =2.205, P =0.000, P =0.025, P =0.000, P =0.015), and no sig-nificant changes in serum immunoglobulins ( t =1.492, P =0.069).Nausea /vomiting, abdominal distension, constipa-tion, dry mouth, poor appetite, poor sleep, bone marrow suppression, cardiac toxicity and other adverse symptoms occurred in 2 patients during chemotherapy, 2 groups of patients the adverse reaction rate comparison, there were no significant differences ( P >0.05).Follow up for 10 -36 months in 2 groups after a median follow-up of 21.7 months; the observation group 3 years survival rate was 40.5%, control group 3 years survival rate was 37.8%, the comparison between the 2 groups, the difference was not statistically significant (χ2 =0.153, P =0.696).Conclusion Chemotherapy combined with blood purifi-cation treatment of multiple myeloma kidney disease with renal insufficiency patients can effectively improve the microcircula-tion, be conducive to improve the clinical effect of chemotherapy, safe and effective, worthy of clinical application.关键词
多发性骨髓瘤肾病/肾功能/血肌酐/血尿酸Key words
Multiple myeloma nephropathy/Renal function/Serum creatinine/Serum uric acid
