诊断学理论与实践2016，Vol.15Issue(5)：513-516,4.DOI:10.16150/j.1671-2870.2016.05.016
超高龄心房颤动患者华法林抗凝过程中心血管不良事件的观察
Warfarin anticoagulation in elderly patients with atrial fibrillation：evaluation by occurrence of adverse cardio-vascular events
摘要
Abstract
Objective: To investigate the occurrence of adverse cardiovascular events in elderly patients with atrial fibrillation (AF) during anticoagulation with warfarin. Methods:One hundred and eight older patients (80 years or older) taking warfarin for AF were enrolled. According to the value of international normalized ratio (INR), patients were divided into 2 groups, low intensity warfarin group (INR between 1.40 and 1.80, n=52) and moderate intensity warfarin group (INR between 1.81 and 2.50, n=56), and effects and safety were compared. All patients were followed up for (1.8 ±1.2) years. The major end point events included the occurrence of ischemic stroke or systemic embolism;the secondary endpoint events included non-fatal myocardial infarction and all causes of death. The safety endpoint events included the occur-rence of the mild, severe and fatal hemorrhage. Results: Embolism occurred in 3 patients (5.36%) in moderate intensity warfarin group and in 6 patients (11.54%) in low intensity warfarin group (all were cerebral stroke);the difference was sta-tistically significant. Conjunctival and nasal hemorrhage occurred in 2 patients in low intensity warfarin group and in 3 pa-tients in moderate intensity warfarin group; no severe hemorrhage was seen in all the patients. No significant difference in hemorrhagic rate was seen between the low intensity and moderate intensity warfarin groups (P>0.05). Conclusions: The INR ranged from 1.81-2.50 is safe for elderly patients with atrial fibrillation treated with warfarin for anticoagulation.关键词
心房颤动/华法林/老年/安全性Key words
Atrial fibrillation/Warfarin/Elder/Safety分类
医药卫生引用本文复制引用
黄红漫,查爽英,刘新兵,柏晓松,冯六六..超高龄心房颤动患者华法林抗凝过程中心血管不良事件的观察[J].诊断学理论与实践,2016,15(5):513-516,4.基金项目
上海市卫生和计划委员会立项课题组 （）
