中国动物检疫2016，Vol.33Issue(11)：1-4,7,5.DOI:10.3969/j.issn.1005-944X.2016.11.001
农村犬狂犬病不同免疫程序的免疫效果比较研究
Comparative Study on Immune Effects of Rabies Vaccination towards Rural Canines by Different Immunization Procedures
蒋碧美 1罗满玉 1吴焕婷 1梁海燕 1夏汉武 1赖俊新 1姚彩兰 1宋伟科 1陈明 1江金初1
作者信息
- 1. 广州市增城区动物卫生监督所，广东广州 511300
- 折叠
摘要
Abstract
Objective]To evaluate the current situation of rabies antibody level of rural canines in Zengcheng district and to compare the immune effects under different vaccination procedures. [Methods]By the methods of questionnaire survey and sampling detection,a certain number of rural canines were randomly sampled and allocated into four groups(group A,B,C and D). Then different vaccination procedures were conducted for these experimental dogs of the above four groups,and serum samples were collected and detected by ELISA for twice. [Results]In the first detection before experimentation,the qualification rates of rabies antibodies were 35.7% and 36.4% respectively, when the experimental dogs were vaccinated in October and November 2014 for the last time. Gender and age were of no significant statistical difference. Results of the second detection(after experimentation)showed that the qualification rates of rabies antibodies of group A(immunized for twice in spring and autumn),group B(only immunized in spring),group C(only immunized in autumn)and group D(no immunization)were 100.0%,66.7%,94.6% and 34.8%,respectively. The data demonstrated that the main effect of immunization in spring and autumn were obvious,but not for the interaction effect. The statistical analysis on the mean antibody titers and qualified rates showed that the differences between group A and B,group A and D,group B and C were significant,the qualified rates of rabies antibodies between group B and D were obvious,but not for the mean antibody titers.[Conclusion]In overall consideration,the immune effects were less affected by gender and age. Once vaccination per year was not enough to maintain the antibody level of the standard(ratio of 70% in the whole year)according to the recommendation of WHO and request of China. And the immunological protection for rural canines would be enhanced effectively under twice immunization per year.关键词
狂犬病/免疫程序/免疫效果调查/析因设计Key words
Rabies/vaccination procedures/immune effect investigation/factorial design分类
农业科技引用本文复制引用
蒋碧美,罗满玉,吴焕婷,梁海燕,夏汉武,赖俊新,姚彩兰,宋伟科,陈明,江金初..农村犬狂犬病不同免疫程序的免疫效果比较研究[J].中国动物检疫,2016,33(11):1-4,7,5.
