局解手术学杂志2016，Vol.25Issue(11)：781-783,784,4.DOI:10.11659/jjssx.03E016095
基于蛋白质互作网络的鼻咽癌基因模块化分析
Gene module analysis of nasopharyngeal carcinoma based on protein-protein interaction network
摘要
Abstract
Objective Based on protein-protein interaction network,gene modules were identified to provide new targets for molecular therapy of nasopharyngeal carcinoma.Methods GEO dataset (GSE12452)and SAMsoftware were employed to screen the differentially ex-pressed gene in nasopharyngeal carcinoma.Protein-protein interaction network was established by using String database.Based on the net-work,the gene modules were identified by using bioinformatics gene module analysis method.GO analysis was used to analyze the function of gene modules.Results In this study,2 634 differentially expressed genes were identified in nasopharyngeal carcinoma.There were 4 729 protein-protein interaction pairs among the differentially expressed genes according to the String database.We established the protein-protein interaction network based on these pairs.Seven gene modules were identified by bioinformatics methods.GO analysis results showed that the function of the gene modules including regulation of cell cycle,glycosylation,cell adhesion,oxidation reduction and so on.Conclusion There are 7 gene modules in protein-protein interaction network in nasopharyngeal carcinoma.These modules may play important roles in the progression and development of nasopharyngeal carcinoma.Our finding can provide a new sight for molecular diagnose and therapy of nasopharyngeal carcinoma.关键词
鼻咽癌/蛋白质互作网络/基因模块化分析Key words
nasopharyngeal carcinoma/protein-protein interaction network/gene module analysis分类
医药卫生引用本文复制引用
张姝,崔晓波,孙娟..基于蛋白质互作网络的鼻咽癌基因模块化分析[J].局解手术学杂志,2016,25(11):781-783,784,4.基金项目
内蒙古自治区自然科学基金（2014MS0856）；内蒙古医科大学科技百万工程项目 （）
