局解手术学杂志2016，Vol.25Issue(11)：789-792,4.DOI:10.11659/jjssx.05E016070
下咽癌中基因功能模块及潜在抗癌药物的筛选
Screening of functional gene modules and the potential anti-cancer drugs in hypopharyngeal cancer
摘要
Abstract
Objective Screening the functional gene modules that can play important roles in hypopharyngeal cancer and the potential anti-cancer drugs.Methods GEO database and MeV software were employed to screen the differentially expressed genes in hypopharyngeal cancer.Using STRING database,the protein-protein interaction network was identified.MCODE plugin of Cytoscape was used to identify the functional gene modules in the network.Based on DAVID database,the functions of modules were identified.DrugBank was used to screen the potential drugs that regulate the target genes of modules.Results 1 222 differentially expressed genes including 219 interaction pairs were i-dentified in whole genome profiling(P <0.05 ).Seven functional modules were identified in the network.The results of function analysis showed the module genes were enriched in cancer development related-function ‘regulation of angiogenesis’,‘cell adhesion’,‘DNA meta-bolic process’.A total of 50 potential drugs that regulating the 5 modules were screened.Conclusion Five functional modules that regulate the progress of hypopharyngeal cancer were identified,and maybe they can promote hypopharyngeal cancer through some functions such as regulation of angiogenesis 18 up-regulated protein kinases were identified.Their kinase inhibitors may potential have a role in anti-cancer, which provides a new target point for molecular therapy of nasopharyngeal cancer.关键词
下咽癌/基因模块/生物信息学/抗癌药物Key words
hypopharyngeal cancer/gene module/bioinformatics/anti-cancer drugs分类
医药卫生引用本文复制引用
孙娟,王薇,胡文良,孙学威,李玲香,崔晓波..下咽癌中基因功能模块及潜在抗癌药物的筛选[J].局解手术学杂志,2016,25(11):789-792,4.基金项目
内蒙古自治区自然科学基金（2014MS0856）；内蒙古医科大学科技百万工程项目 （）
