中国临床医学2016，Vol.23Issue(4)：415-421,7.DOI:10.12025/j.issn.1008-6358.2016.20151059
C反应蛋白基因rs2808630、吸烟与非小细胞肺癌易感性的相关性
C-reactive protein rs2808630 T>C in smokers increases non-small cell lung cancer susceptibility
摘要
Abstract
Objective:To explore the association between C reactive protein (CRP) rs2808630 and non‐small cell lung cancer (NSCLC) .Methods:CRP rs2808630 Genotyping of 974 NSCLC patients and 1 005 healthy controls from Shanghai and Taizhou of Jiangsu Province based on double ligation and multiplex fluorescence PCR .The effect of rs2808630 on NSCLC susceptibility was analyzed .Results:Compared with TT genotype ,rs2808630 TC genotype significantly increased NSCLC risk (P=0 .034) ,but this association became insignificant after adjusting with age ,gender ,smoking status ,and family history . However ,in the subgroup of smokers ,TC genotype was significantly associated with increased NSCLC risk after adjustment (OR=1 .329 ,95% CI 1 .017‐1 .736 , P=0 .037) .In addition ,TC genotype exhibited a significantly elevated risk of squamous cell carcinoma (OR=1 .383 ,95% CI 1 .023‐1 .870 ,P=0 .035) .Further stratified analysis revealed that TC genotype posed a much higher risk of squamous cell carcinoma among smokers (OR=1 .479 ,95% CI 1 .058‐2 .067 , P=0 .022) .Conclusions:The interaction between rs2808630 T> C and smoking behavior might play an important role in leading to NSCLC especially squamous cell carcinoma .关键词
C反应蛋白/rs2808630位点/病例-对照研究/吸烟/非小细胞肺癌Key words
C-reactive protein/rs2808630/case-control study/smoking/non-small cell lung cancer分类
医药卫生引用本文复制引用
李玉涛,王久存,钱成,吴俊杰,王一,徐月娟,张艳红,郭士成,赵振宏,李强,卢大儒,金力..C反应蛋白基因rs2808630、吸烟与非小细胞肺癌易感性的相关性[J].中国临床医学,2016,23(4):415-421,7.基金项目
国家自然科学基金（81372236），国家科技支撑计划重点项目（2011BAI09B00），上海博士后科学基金（12R21411500），上海市科学技术委员会科研计划项目（12nm0500900），上海国际合作基金项目（14430712002），复旦大学高端计算中心支持项目．Supported by National Natural Science Foundation of China （81372236），Key Projects in the National Science& Technology Pillar Program （2011BAI09B00），Shang-hai Postdoctoral Science Foundation （12R21411500），Shanghai Science and Technology Research Program （12nm0500900），Shanghai Founda-tion for International Cooperation （14430712002） and Fudan University High-End Computing Center Fund ． （）
