中国临床医学2016，Vol.23Issue(4)：437-439,3.DOI:10.12025/j.issn.1008-6358.2016.20160638
胃癌患者血清miRNA-223的表达水平及其诊断价值
Diagnostic value and expression of serum miRNA-223 in patients with gastric cancer
刘海宁 1朱新宇 1吴昊 1陈玉琢 1英和娜拉 1刘韬韬1
作者信息
- 1. 复旦大学附属中山医院消化内科，上海 200032
- 折叠
摘要
Abstract
Objective:To discuss the expression and diagnostic value of miRNA‐223 in patients with gastric cancer . Methods:The expression of serum miRNA‐223 was detected in 50 patients with gastric cancer and 50 healthy controls by using real‐time quantitative reverse transcription polymerase chain reaction (qRT‐PCR ) . The relationship of miRNA‐223 and clinicpathological parameter of gastric cancer was analyzed . The receiver operating curve (ROC ) was constructed and the diagnostic value of miRNA‐223 and carcinoembryonic antigen (CEA) was compared .Results: The serum miRNA‐223 in patients with gastric cancer was significantly higher than control group .The ROC indicated that area under the ROC curve (AUC) of miRNA‐223 was 0 .636 (95% CI 0 .526‐0 .746) with sensitivity of 48% and specificity of 82% while AUC of combination of miRNA‐223 and CEA was 0 .769 (95% CI 0 .675‐0 .862) with sensitivity of 70% and specificity of 78% . Conclusions:Combining miRNA‐223 and CEA can be used to diagnosis gastric cancer .关键词
胃癌/miRNA-223/诊断价值Key words
gastric cancer/miRNA-223/diagnostic value分类
医药卫生引用本文复制引用
刘海宁,朱新宇,吴昊,陈玉琢,英和娜拉,刘韬韬..胃癌患者血清miRNA-223的表达水平及其诊断价值[J].中国临床医学,2016,23(4):437-439,3.
