中国临床医学2016，Vol.23Issue(4)：473-476,4.DOI:10.12025/j.issn.1008-6358.2016.20160501
血人绒毛膜促性腺激素对葡萄胎恶变的早期预测价值
Early prediction value of blood human chorionic gonadotropin level for post-mole gestational trophoblastic neoplasia
摘要
Abstract
Objective:To identify the clinical factors associated with hydatidiform mole and to investigate the early prediction effect of dynamic monitoring of blood human chorionic gonadotropin(hCG) for gestational trophoblastic neoplasia (GTN) .Methods:The clinical data of 102 cases of hydatidiform mole diagnosed and treated in Nanjing Maternity and Child Health Care Hospital of Nanjing Medical University were analyzed ,among which 50 cases developed into GTN .The univariate analysis method was used to analyze the correlation between age ,childbearing history ,pregnancy time ,blood hCG levels before treatment ,one day after curettage and one week after curettage with post‐mole GTN .The ROC curve analysis was used to analyze the predictive value of blood hCG levels one day and one week after curettage for post‐mole GTN .Results: The differences in age ,blood hCG levels one day and one week after curettage between the malignant group and the cure group were statistically significant (P<0 .05) .The area under the curve (AUC) of the blood hCG level one day after curettage predicting GTN was 0 .60 ± 0 .04 ,sensitivity 40 .4% ,specificity 77% ,and the cut‐off point was 9 300 mIU/mL .The AUC of the blood hCG level one week after curettage predicting GTN was 0 .82 ± 0 .03 ,sensitivity 71 .6% ,specificity 80 .8% ,and the cut‐off point was 6 567 mIU/mL .Conclusions:Age ,blood hCG levels one day and one week after curettage were independent risk factors associated with post‐mole GTN . The blood hCG level one week after curettage is the most reliable and strongest predicative factor for post‐mole GTN .关键词
葡萄胎/侵蚀性葡萄胎/人绒毛膜促性腺激素/预测/临床因素Key words
hydatidiform mole/gestational trophoblastic neoplasia/human chorionic gonadotropin/prediction/clinical factors分类
医药卫生引用本文复制引用
朱烨,苏亦平,周璘,周娟..血人绒毛膜促性腺激素对葡萄胎恶变的早期预测价值[J].中国临床医学,2016,23(4):473-476,4.基金项目
江苏省妇幼保健科研项目（F201211），南京市科技发展项目（201503049）．Supported by Maternal and Child Health Research Project of Jiangsu Province （F201211） and Nanjing Science and Technique Development Foundation （201503049）． （）
