摘要
Abstract
Objective:To investigate dynamic change of T helper 17 cells (Th17) and regulatory T cells(Treg) frequency in hepatitis B e antigen (HBeAg ) positive chronic hepatitis B patients receiving nucleoside analogues treatment . Methods:A total of 30 chronic hepatitis B patients with positive HBeAg were enrolled .All the patients received telbivudine antiviral treatment .The peripheral blood Treg cell frequency ,Th17 cell frequency and Th17/Treg ratio were detected before treatment and at 4th ,8th ,12th ,24th ,36th ,48th weeks after treatment .The total bilirubin in serum (TBIL) ,direct bilirubin in serum (DBIL ) ,alanine transaminase (ALT ) ,aspertate aminotransferase (AST ) ,hepatitis B virus DNA (HBV‐DNA ) and HBeAg level were detected and compared between before and after treatment .The correlations of Treg cell frequency and Th17 cell frequency with the indexes of TBIL ,DBIL ,ALT ,AST ,HBV‐DNA ,HBeAg were analyzed ,respectively .Results:Treg cell frequency was decreased then increased and reached the minimum point at 8th weeks after treatment .Th17 cell frequency decreased during treatment ;and Th17/Treg ratio decreased and was stable at 24th ,36th ,48th week after treatment .The levels of TBIL ,DBIL ,ALT ,AST ,HBV‐DNA and HBeAg were significantly decreased after treatment (P< 0 .05) .Treg cell frequency was positively correlated with HBV‐DNA and HBeAg levels ( P< 0 .05 ) . Th17 cell frequency was positively correlated with TBIL ,DBIL ,ALT and AST levels (P<0 .05) .Conclusions:Treg cell frequency ,Th17 cell frequency and Th17/Treg ratio shows dynamic changes during nucleoside analogues treatment for HBeAg positive chronic hepatitis B patients .They are correlated with liver function indexes after treatment ;they can provide evidence for clinical treatment and prognosis evaluation .关键词
慢性乙型肝炎/替比夫定/Th17细胞/Treg细胞Key words
chronic hepatitis B/telbivudine/Th17 cell/Treg cell分类
医药卫生
