中国临床医学2016，Vol.23Issue(4)：514-518,5.DOI:10.12025/j.issn.1008-6358.2016.20160098
阿尔兹海默病睡眠障碍的机制与治疗进展
Mechanism and treatment of sleep disorders in Alzheimer’s disease
摘要
Abstract
Alzheimer's disease (AD) is a neurodegenerative disease highly correlated with age and characterized by progressive impairment in memory and cognition ,also known as senile dementia .Survey shows more than 40% of AD patients with varying degrees of sleep problems (sleep structure changes ,circadian rhythm disorder ,sleep apnea and so on) ,which can lead to accelerated cognitive and behavioral deterioration ,the nerve‐endocrine system dysfunction ,emotional irritability and depression ,and even death .Due to the poor efficacy of first‐line treatment drugs ,and no significant positive results were achieved in AD drug development over the past ten years ,how to effectively improve the associated symptoms of AD has become one of the therapeutic targets for delaying the progression of AD .In the past 5 years ,research on the relationship between sleep and AD ,related drugs and non‐drug therapy has attracted increasing attention .In this paper ,a review of the pathogenesis and clinical treatment of sleep disorders in patients with AD will be presented .关键词
睡眠障碍/阿尔兹海默病/机制/治疗Key words
sleep disorders/Alzheimer's disease/pathogenesis/treatment分类
医药卫生引用本文复制引用
孙文静,贺斌,尹又..阿尔兹海默病睡眠障碍的机制与治疗进展[J].中国临床医学,2016,23(4):514-518,5.基金项目
国家自然科学基金（30900473，81371459，81171252），国家科技部重大专项（2011ZXJ09202-015），国家科技支撑计划项目（2015BAI13B01），上海市科学技术委员会重点项目（11411950203），上海市自然科学基金（15ZR1414600）．Supported by National Natural ScienceFoundationofChina（30900473，81371459，81171252），NationalMinistryofScienceandTechnologyMajorProject（2011ZXJ09202-015），National Key Technology Research and Development Program of Ministry of Science and Technology of China （2015BAI13B01），Medical Key Project of Shanghai Municipal Science and Technology Commission （11411950203） and Natural Science Foundation of Shanghai （15ZR1414600）． （）
