中国药房2016，Vol.27Issue(31)：4347-4349,4350,4.DOI:10.6039/j.issn.1001-0408.2016.31.08
白及多糖对血热出血模型大鼠的止血作用及机制研究
Study on Hemostatic Effect and Mechanism of Polysaccharides from Bletilla striata in Blood Heat and Hemorrhage Model Rats
摘要
Abstract
OBJECTIVE:To study the hemostatic effect and mechanism of the polysaccharides from Bletilla striata in blood heat and hemorrhage(BBH)model rats. METHODS:Rats were randomly divided into normal control group,model group,Yun-nan baiyao group (0.50 g/kg),and BSP low-dose,medium-dose and high-dose groups (0.34,0.68,1.35 g/kg),with 10 rats in each group. Except for normal control group,those groups were given water decoction of Rhizoma Zingiberis and 5%ethanol to in-duce BBH model. After modeling,those groups were given relevant medicine intragastrically,once a day,for 14 days,except nor-mal control group and model group were given normal saline intragastrically. 1 h after last administration,body weight,food in-take,water intake,the rate of platelet aggregation,the contents of t-PA and PAI-1,pathological change of lung and stomach were all detected in each group. RESULTS:Compared with normal control group,body weight,food intake,maximal rate of platelet ag-gregation and the content of PAI-1 were decreased in model group;while water intake,the content of t-PA and ratio of t-PA/PAI-1 were increased (P<0.05 or P<0.01). Moreover,hemorrhage and inflammation of lung and stomach were found. Compared with model group,the body weight and food intake of Yunnan baiyao group,BSP low-dose,medium-dose and high-dose groups were increased,while water intake were decreased (P<0.05 or P<0.01);the maximal rate of platelet aggregation and the content of PAI-1 were increased in Yunnan baiyao group,BSP medium-dose and high-dose groups,while ratio of t-PA/PAI-1 were decreased (P<0.05 or P<0.01),the pathological changes of lung and stomach relieved to varying degrees. CONCLUSIONS:BSP exerts he-mostatic effect by up-regulating the rate of platelet aggregation,rising fibrinolysis systems,improving the lesion of lung and stom-ach.关键词
白及多糖/血热出血/大鼠/血小板聚集/纤溶系统/组织病理学检查Key words
Polysaccharides from Bletilla striata/Blood heat and hemorrhage/Rats/Platelet aggregation/Fibrinolytic system/Histopathological examination分类
医药卫生引用本文复制引用
董永喜,刘星星,董莉,王霞,黄勇,王永林..白及多糖对血热出血模型大鼠的止血作用及机制研究[J].中国药房,2016,27(31):4347-4349,4350,4.基金项目
国家自然科学基金资助项目（No.81360636，81460630）；贵州省优秀青年科技人才专项（No.黔科合人字〔2015〕11号）；贵州省高等学校创新能力提升计划 （）
