中国药房2016，Vol.27Issue(31)：4350-4352,3.DOI:10.6039/j.issn.1001-0408.2016.31.09
救必应酸琥珀酰酯在大鼠体内的药动学和绝对生物利用度研究
Pharmacokinetics and Absolute Bioavailability Study of Succinyl Rotundic Acid in Rats
摘要
Abstract
OBJECTIVE:To study the pharmacokinetics and absolute bioavailability of succinyl rotundic acid (SRA) in rats. METHODS:Wistar rats were randomly divided into intragastric injection(ig)group(30 mg/kg)and tail intravenous injection(iv) group (15 mg/kg),with 10 rats in each group. They were given SRA with relevant usage and dosage. The blood sample of tail vein 0.2 ml was respectively taken after 5,10,20,30,40,60,90,150,210,270,390,510 min of administration. The plasma concen-tration of SRA was determined by RP-HPLC using tanshinone ⅡA as internal standard. The pharmacokinetic parameters and abso-lute bioavailability were calculated by using 3p97 software. RESULTS:The pharmacokinetic parameters of ig group were that cmax was(1.02±0.27)μg/ml,tmax was(26.64±2.74)min,t1/2 was(42.79±3.46)min and AUC0-510 min was(92.27±9.26)μg·min/ml;those of tail iv group were that t1/2 was(17.21±1.58)min,and AUC0-510 min was(320.50±11.89)μg·min/ml. Oral obsolute bioavail-ability of SRA was 14.40%. CONCLUSIONS:The pharmacokinetic characteristics of SRA in rats conform to one-compartment model,and the absolute bioavailability is high.关键词
救必应酸琥珀酰酯/反相-高效液相色谱法/大鼠/药动学/绝对生物利用度Key words
Succinyl rotundic acid/RP-HPLC/Rats/Pharmacokinetics/Absolute bioavailability分类
医药卫生引用本文复制引用
赫玉芳,南敏伦,赵昱玮,吕娜,李阔,王文君,何忠梅..救必应酸琥珀酰酯在大鼠体内的药动学和绝对生物利用度研究[J].中国药房,2016,27(31):4350-4352,3.基金项目
国家自然科学基金资助项目 （）
