中国药房2016，Vol.27Issue(31)：4360-4362,4363,4.DOI:10.6039/j.issn.1001-0408.2016.31.12
替硝唑对盆腔炎模型大鼠血浆和子宫组织中左氧氟沙星药动学的影响
Effects of Tinidazole on the Pharmacokinetinetics of Levofloxacin in Plasma and Uterine Tissue of Pelvic Inflammatory Model Rats
摘要
Abstract
OBJECTIVE:To investigate the effects of tinidazole on the pharmacokinetinetics of levofloxacin(LVFX)in plasma and uterine tissue of pelvic inflammatory model rats. METHODS:Female rats were selected to establish chronic pelvic inflamma-tion model. Those model rats were randomly divided into experimental group (tinidazole 100 mg/kg+lactic acid LVFX suspension 80 mg/kg)and control group(lactic acid LVFX suspension 80 mg/kg),with 48 rats in each group. They were given relevant medi-cine intragastrically 4th day after modeling. 6 rats were respectively sacrificed 0.25,0.5,1,1.5,2,4,8 and 12 h after medica-tion. The plasma and uterine samples were collected. Using ciprofloxacin as internal standard,the concentrations of LVFX in plas-ma and uterine tissue were detected by HPLC,and the pharmacokinetic parameters were calculated with DAS 2.0 software. RE-SULTS:Plasma concentration-time curves of LVFX in plasma and uterine tissue of rats in experimental group and control group both fit the two-compartment model. The main pharmacokinetics parameters as follows as cmax were (15.17 ± 0.87) vs. (14.94 ± 0.46)μg/ml for plasma,(14.18±1.20)vs.(11.86±0.84) μg/ml for uterine tissue;tmax were(1.42±0.20)vs.(1.5±0.01)h for plasma,(1.25±0.27)vs.(1.17±0.26)h for uterine tissue;t1/2β were(7.69±2.61)vs.(7.32±2.80)h for plasma,(7.95±5.29) vs. (9.16 ± 3.00) h for uterine tissue;AUC0-12 h were (52.65 ± 6.07) vs. (51.15 ± 3.53)μg·h/ml for plasma,(52.92 ± 5.87) vs. (42.59 ± 3.91)μg·h/ml for uterine tissue;AUC0-∞ were(61.27 ± 7.93) vs.(58.86 ± 4.58)μg·h/ml for plasma,(60.64 ± 7.20) vs. (47.41 ± 4.75)μg·h/ml for uterine tissue;CL/F were (1.37 ± 0.26) vs. (1.35 ± 0.10) L/(kg·h) for plasma,(1.32 ± 0.16) vs. (1.67±0.17)L/(kg·h)for uterine tissue. There were statistical significance in cmax,AUC0-12 h,AUC0-∞ and CL/F of uterine tissue between 2 groups(P<0.05). CONCLUSIONS:Tinidazole can obviously increase the distribution of LVFX in the uterine tissue of pelvic inflammatory model rats,reduce the elimination rate but has no effect on the distribution of LVFX in plasma.关键词
替硝唑/左氧氟沙星/盆腔炎/药动学/雌性/大鼠Key words
Tinidazole/Levofloxacin/Pelvic inflammation/Pharmacokinetics/Female/Rats分类
医药卫生引用本文复制引用
黄艳,孔令希,王宁..替硝唑对盆腔炎模型大鼠血浆和子宫组织中左氧氟沙星药动学的影响[J].中国药房,2016,27(31):4360-4362,4363,4.基金项目
重庆市卫生计生委医学科研计划项目 （）
