中国药房2016，Vol.27Issue(31)：4373-4375,3.DOI:10.6039/j.issn.1001-0408.2016.31.16
红毛鸡干燥体醇提物对血虚模型小鼠的补血作用研究
Study on Blood Enriching Effect of Centropus sinensis Dried Body Alcohol Extract on Blood-deficiency Model Mice
摘要
Abstract
OBJECTIVE:To study blood enriching effect of Centropus sinensis dried body alcohol extract on the blood-deficien-cy model mice. METHODS:60 mice were randomly divided into normal group,model group,positive control group(Compound E’jiaojiang,0.1 ml/10 g)and C. sinensis dried body alcohol extract low-dose,medium-dose and high-dose groups(2.5,5.0,10.0 g/kg),with 10 mice in each group. Except for normal group,other groups were hypodermically injected with APH saline solution on 2nd day and 5th day,and then intraperitoneally injected with CTX saline solution from 6th day to 9th day respectively,which was to establish the blood-deficiency model. From the 1st day,the mice in normal group and model group were intragastrically giv-en constant volume of distilled water,and treatment groups were given relevant medicine intragastrically,once a day,for consecu-tive 9 days. At the end of treatment,WBC,RBC,HGB and HCT were detected by automatic hematological analysis;the thymus index,spleen index,liver index were counted;and the activities of Na+-K+-ATPase,Ca2+-Mg2+-ATPase of red cell membrane and T-AOC and SOD in liver were determined with kits respectively. RESULTS:Compared with normal group,WBC,RBC,HGB, HCT,thymus index,the activities of Na+-K+-ATPase,Ca2+-Mg2+-ATPase,T-AOC and SOD of model group were decreased signifi-cantly,while spleen index and liver index were increased significantly (P<0.01). Compared with model group,WBC,RBC, HGB,HCT,thymus index,the activities of Na+-K+-ATPase,Ca2+-Mg2+-ATPase,T-AOC and SOD of C. sinensis dried body alco-hol extract groups and positive control group were increased significantly;the spleen index and liver index were decreased signifi-cantly in C. sinensis dried body alcohol extract medium-dose and high-dose groups and positive control group (P<0.05 or P<0.01). CONCLUSIONS:C. sinensis dried body alcohol extract shows a certain effect on blood enriching by improving peripheral blood routine and organic function of blood-deficiency model mice.关键词
红毛鸡/干燥体/醇提物/血虚模型/补血/小鼠Key words
Centropus sinensis/Dried body/Alcohol extract/Blood-deficiency model/Blood enriching/Mice分类
医药卫生引用本文复制引用
曾繁强,徐永莉,江思华,张月云,赵成坚,李力..红毛鸡干燥体醇提物对血虚模型小鼠的补血作用研究[J].中国药房,2016,27(31):4373-4375,3.基金项目
广西科学研究与技术开发计划项目（No.桂科重12118005-2-5）；南宁市科学研究与技术开发计划项目（No.20123238）；广西医疗卫生重点科研课题 （）
