中国药房2016，Vol.27Issue(31)：4388-4390,4391,4.DOI:10.6039/j.issn.1001-0408.2016.31.21
新疆阿魏乙酸乙酯部位对小鼠S180实体瘤的抑制作用
Inhibitory Effect of Ethyl Acetate Part of Ferula sinkiangensis on S180 Solid Tumor in Mice
摘要
Abstract
OBJECTIVE:To study the inhibitory effect of ethyl acetate part from Ferula sinkiangensis on S180 solid tumor in mice.METHODS:60 mice were randomly divided into normal control group,tumor model group,ethyl acetate part of F. sinkian-gensis low-dose,middle-dose and high-dose groups(1.0,2.0,3.0 g/kg,ig),cisplatin control group(positive drug,5 mg/kg,iv), with 10 mice in each group. Except for normal control group,other groups were given mice ascites infected by S180 solid tumor to induce S180 solid tumor model. The next day after modeling,those groups were given relevant medicine,and normal control group and tumor model group were given constant volume of normal saline,once a day,for consecutive 10 days. Body weight,organ (spleen,thymus)index,the change of tumor volume,volume and weight of solid tumor,inhibitory rate of tumor and pathological change were observed in each group. ELISA method was used to determined the serum levels of IL-2,IFN-γ and TNF-α. RE-SULTS:Compared with normal control group,spleen index and TNF-α of tumor model group were increased significantly,while IL-2 and IFN-γ were decreased significantly (P<0.05);dysplastic cells of tumor tissue appeared lumpy,accompanied by a num-ber of ischemic necrosis of dysplastic cells. Compared with tumor model group,body weight,spleen index,thymus index and vol-ume and weight of solid tumor in cisplatin control group were decreased significantly,while IL-2 and TNF-α levels were increased significantly. The spleen index and TNF-α level of ethyl acetate part of F. sinkiangensis groups were increased significantly,while the volume and weight of solid tumor were decreased significantly(P<0.05). The tumor tissue was inhibited to different extents, especially in cisplatin control group;the number of tumor cells was decreased,accompanied by small number of cellular necrosis and infiltration. Inhibitory rates of cisplatin control group,ethyl acetate part of F. sinkiangensis groups were (73.26 ± 4.55)%, (40.34±3.45)%,(50.86±9.34)%,(58.20±3.70)%,respectively. CONCLUSIONS:ethyl acetate part of F. sinkiangensis can in-hibit S180 solid tumor in mice.关键词
维药/新疆阿魏/乙酸乙酯部位/S180实体瘤/抑瘤作用/小鼠Key words
Uygur medicine/Ferula sinkiangensis/Ethyl acetate part/S180 solid tumor/Tumor inhibitory effect/Mice分类
医药卫生引用本文复制引用
罗福祥,卢军,张海英,雷亚江,张洪平..新疆阿魏乙酸乙酯部位对小鼠S180实体瘤的抑制作用[J].中国药房,2016,27(31):4388-4390,4391,4.基金项目
国家自然科学基金资助项目 （）
