中国药房2016，Vol.27Issue(31)：4436-4438,4439,4.DOI:10.6039/j.issn.1001-0408.2016.31.34
琥珀酸去甲文拉法辛缓释微丸胶囊的制备及微丸体外释药研究
Study on Preparation of Desvenlafaxine Succinate Sustained-release Pellets Capsules and Drug Release in vitro of Pellets
陈才 1何芳 1龙锐1
作者信息
- 1. 重庆医科大学附属第一医院药学部，重庆 400016
- 折叠
摘要
Abstract
OBJECTIVE:To prepare Desvenlafaxine succinate(DVS)sustained-release pellets capsules,and to investigate the release property in vitro of pellets. METHODS:The pellets containing DVS were prepared by alcohol solution. The quality and mi-cromeritics of DVS pellets were studied. Using ethylcellulose(EC)and hydroxypropyl methyl cellulose(HPMC)as coating materi-als,DVS sustained-release pellets were prepared by fluid-bed,and then put into enteric hollow capsule. The release property in vi-tro of DVS sustained-release pellets,and the effects of different drying time (1-24 h) and artificial gastric juice on drug release were investigated. RESULTS:DVS pellets and DVS sustained-release pellets were smooth and had scattered ostiole in surface. The content of DVS in DVS pellets was 19.56%(RSD=0.53%,n=10),and drug-loading rate was 94%;bulk density was 0.792 1 g/ml;roundness degree was 7.84 °;angle of repose was 21.3 °. There was no statistical significance in the difference of drug release for DVS sustained-release pellets after dried for different time (P>0.05),and accumulative release rate decreased 3 h after treated with artificial gastric juice;the release regularity of DVS sustained-release pellets fitted to first-order kinetic equation. CONCLU-SIONS:DVS sustained-release capsules are prepared successfully by this method,and can be not dried during preparation.关键词
琥珀酸去甲文拉法辛/缓释微丸/流化床包衣/体外释药/制备Key words
Desvenlafaxine succinate/Sustained-release pellet/Fluid-bed coating/Drug release in vitro/Preparation分类
医药卫生引用本文复制引用
陈才,何芳,龙锐..琥珀酸去甲文拉法辛缓释微丸胶囊的制备及微丸体外释药研究[J].中国药房,2016,27(31):4436-4438,4439,4.
