中国药理学通报2016，Vol.32Issue(11)：1490-1493,4.DOI:10.3969/j.issn.1001-1978.2016.11.003
NOXs在肝纤维化中的作用机制研究
Study on mechanism of NOXs in liver fibrosis
摘要
Abstract
Nicotinamide adenine dinucleotide phosphate oxidase ( NOXs) contributes to the production of reactive oxygen species ( ROS) in liver fibrosis, resulting in the activation of endoplas-mic reticulum stress ( ERS ) and IRE1α-XBP1 signaling path-way. ROS is a series of oxygen metabolites and its derivatives, produced by the single electron reduction of molecular oxygen ( O2 ) , including superoxide anion ( O2- ) , hydroxyl radical (-OH) , hydrogen peroxide ( H2 O2 ) , hypochlorite ion ( OCl-) and so on. They can interact with a large number of molecules, including small inorganic molecules, proteins, lipids, carbohy-drates and nucleic acids, resulting in lipid peroxidation of cell damaging molecules. And as a second messenger, ROS can also affect the proliferation and activation of HSC in liver fibrosis, and induce the hepatocyte apoptosis through a variety of cellular signal transduction. Here we review the current status of the study on the mechanism of NOXs in liver fibrosis.关键词
肝纤维化/NOXs/肝细胞凋亡/炎症反应/氧化应激/内质网应激/IRE1α-XBP1信号通路Key words
liver fibrosis/NOXs/hepatocyte apoptosis/inflam-mation/oxidative stress/endoplasmic reticulum stress/IRE1α-XBP1 signaling pathway分类
医药卫生引用本文复制引用
卞勉励,陈星燃,张晨曦,金欢欢,赵士峰,张峰,郑仕中..NOXs在肝纤维化中的作用机制研究[J].中国药理学通报,2016,32(11):1490-1493,4.基金项目
国家自然科学基金资助项目( No 81270514,31401210,31571455) （ No 81270514,31401210,31571455）
江苏省自然科学基金青年基金资助项目( No BK20140955) （ No BK20140955）
江苏省高校自然科学研究面上项目( No 14KJB310011) （ No 14KJB310011）
2013年江苏高校优秀科技创新团队计划 （）
江苏高校优势学科建设工程资助项目( No ysxk-2010) （ No ysxk-2010）
南京市医学科技发展项目(No YKK14143) （No YKK14143）
