中国药理学通报2016，Vol.32Issue(11)：1505-1509,5.DOI:10.3969/j.issn.1001-1978.2016.11.006
衰老相关分泌表型的研究进展
The research progress of senescence-associated secretory phenotype
摘要
Abstract
When senescence induction is based on DNA damage, senescent cells display a unique phenotype, which has been termed “senescence-associated secretory phenotype”( SASP ) . SASP, including proinflammatory cytokines, growth factors, chemokines, matrix remodeling enzymes and other cytokines, may be an important driver of chronic inflammation and therefore may be part of a vicious cycle of inflammation, DNA damage and senescence. Senescence-associated secretory products released by such cells can affect the neighboring cells and further exacer-bate their regenerative capacity. SASP is associated with many chronic age-related diseases.关键词
细胞衰老/衰老相关分泌表型/SASP/炎症/衰老机制/衰老相关疾病Key words
cellular senescence/senescence-associated secreto-ry phenotype/SASP/inflammation/aging mechanism/age-re-lated diseases分类
医药卫生引用本文复制引用
郭慧宁,凌霜,刘俊,李玉凤,王淑荣,党延启,陈小淼,许锦文..衰老相关分泌表型的研究进展[J].中国药理学通报,2016,32(11):1505-1509,5.基金项目
国家自然科学基金资助项目( No 81274130) （ No 81274130）
上海市教委085项目高等教育内涵建设基金项目(No 085ZY1202) （No 085ZY1202）
