中国医院用药评价与分析2016，Vol.16Issue(10)：1308-1310,3.DOI:10.14009/j.issn.1672-2124.2016.10.004
黄连解毒汤治疗肝炎和肝纤维化的网络药理学研究
Network Pharmacology Study on Huanglianjiedu Decoction in Treatment of Hepatitis and Liver FibrosisΔ
摘要
Abstract
OBJECTIVE:To probe into the mechanism of therapeutic action of Huanglianjiedu decoction in treatment of hepatitis and liver fibrosis through network pharmacology . METHODS: To select the targets of Huanglianjiedu decoction through TDT database and PharmMapper Server data base; and to select the targets of hepatitis and liver fibrosis through OMIM database.The targets of the data were analyzed with PPI database, and then the interactive network of “compound-target-disease” could be obtained; in addition, and the interactive network Xgmml was analyzed with Cytoscapy 3.0 software for network visualization and the topology parameter value of the dots, and the mechanism of therapeutic action of Huanglianjiedu decoction was obtained.RESULTS:The therapeutic effects of Huanglianjiedu decoction in treatment of hepatitis might concentrate on intervening the related signaling pathways of the Galectin-3, epidermal growth factor receptor, PI3-kinase subunit p85-alpha; while the liver fibrosis might concentrate on intervening the related signaling pathways of the Galectin-3.CONCLUSIONS: Huanglianjiedu decoction can in treatment of hepatitis through intervening the related signaling pathways of the Galectin-3 , and prevent the development of hepatitis to liver fibrosis.Meanwhile, network pharmacology method can be regarded as the prediction method of computer in biological mechanism of medication treatment for the specific diseases, which can be regarded as a good method for the discovery and research of medicine.关键词
黄连解毒汤/肝炎/肝纤维化/网络药理学Key words
Huanglianjiedu decoction/Hepatitis/Liver fibrosis/Network pharmacology分类
医药卫生引用本文复制引用
魏士长,吴明权,王欢,黄银秋,周厚琴,张璐,赵艳玲..黄连解毒汤治疗肝炎和肝纤维化的网络药理学研究[J].中国医院用药评价与分析,2016,16(10):1308-1310,3.基金项目
国家自然科学基金资助项目 （）
